Cannabinor (PRS-211,375) is a drug which acts as a potent and selective
cannabinoidCB2receptoragonist.[1][2] It is classed as a "nonclassical" cannabinoid with a chemical structure similar to that of
cannabidiol. It has a CB2 affinity of 17.4 nM vs 5,585 nM at CB1, giving it over 300× selectivity for CB2.[3] It showed
analgesic effects in animal studies especially in models of
neuropathic pain, but failed in Phase IIb human
clinical trials due to lack of efficacy.[4]
^Gratzke C, Streng T, Stief CG, Downs TR, Alroy I, Rosenbaum JS, Andersson KE, Hedlund P (June 2010). "Effects of cannabinor, a novel selective cannabinoid 2 receptor agonist, on bladder function in normal rats". European Urology. 57 (6): 1093–100.
doi:
10.1016/j.eururo.2010.02.027.
PMID20207474.
^Gratzke C, Streng T, Stief CG, Alroy I, Limberg BJ, Downs TR, et al. (February 2011). "Cannabinor, a selective cannabinoid-2 receptor agonist, improves bladder emptying in rats with partial urethral obstruction". The Journal of Urology. 185 (2): 731–6.
doi:
10.1016/j.juro.2010.09.080.
PMID21168864.
^Nevalainen T (2013). "Recent development of CB2 selective and peripheral CB1/CB2 cannabinoid receptor ligands". Current Medicinal Chemistry. 21 (2): 187–203.
doi:
10.2174/09298673113206660296.
PMID24164198.
Cannabinor (PRS-211,375) is a drug which acts as a potent and selective
cannabinoidCB2receptoragonist.[1][2] It is classed as a "nonclassical" cannabinoid with a chemical structure similar to that of
cannabidiol. It has a CB2 affinity of 17.4 nM vs 5,585 nM at CB1, giving it over 300× selectivity for CB2.[3] It showed
analgesic effects in animal studies especially in models of
neuropathic pain, but failed in Phase IIb human
clinical trials due to lack of efficacy.[4]
^Gratzke C, Streng T, Stief CG, Downs TR, Alroy I, Rosenbaum JS, Andersson KE, Hedlund P (June 2010). "Effects of cannabinor, a novel selective cannabinoid 2 receptor agonist, on bladder function in normal rats". European Urology. 57 (6): 1093–100.
doi:
10.1016/j.eururo.2010.02.027.
PMID20207474.
^Gratzke C, Streng T, Stief CG, Alroy I, Limberg BJ, Downs TR, et al. (February 2011). "Cannabinor, a selective cannabinoid-2 receptor agonist, improves bladder emptying in rats with partial urethral obstruction". The Journal of Urology. 185 (2): 731–6.
doi:
10.1016/j.juro.2010.09.080.
PMID21168864.
^Nevalainen T (2013). "Recent development of CB2 selective and peripheral CB1/CB2 cannabinoid receptor ligands". Current Medicinal Chemistry. 21 (2): 187–203.
doi:
10.2174/09298673113206660296.
PMID24164198.