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Identifiers | |
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PubChem CID | |
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ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C21H22BrNO |
Molar mass | 384.317 g·mol−1 |
3D model ( JSmol) | |
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(what is this?) (verify) |
JWH-249 (1-pentyl-3-(2-bromophenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 2.4 times selectivity for CB1 with a Ki of 8.4 ± 1.8 nM and 20 ± 2 nM at CB2. Similar to the related 2'- methoxy compound JWH-250, the 2'- chloro compound JWH-203, and the 2'- methyl compound JWH-251, JWH-249 has a phenyl acetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds. [1] [2]
In the United States, CB1 receptor agonists of the 3-phenylacetylindole class such as cannabipiperidiethanone are Schedule I Controlled Substances. [3]
Legal status | |
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Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C21H22BrNO |
Molar mass | 384.317 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
JWH-249 (1-pentyl-3-(2-bromophenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 2.4 times selectivity for CB1 with a Ki of 8.4 ± 1.8 nM and 20 ± 2 nM at CB2. Similar to the related 2'- methoxy compound JWH-250, the 2'- chloro compound JWH-203, and the 2'- methyl compound JWH-251, JWH-249 has a phenyl acetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds. [1] [2]
In the United States, CB1 receptor agonists of the 3-phenylacetylindole class such as cannabipiperidiethanone are Schedule I Controlled Substances. [3]