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Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.233.198 |
Chemical and physical data | |
Formula | C22H30N2O2 |
Molar mass | 354.494 g·mol−1 |
3D model ( JSmol) | |
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(what is this?) (verify) |
A-796,260 is a drug developed by Abbott Laboratories that acts as a potent and selective cannabinoid CB2 receptor agonist. Replacing the aromatic 3- benzoyl or 3- naphthoyl group found in most indole derived cannabinoids with the 3- tetramethyl cyclopropyl methanone group, imparts significant selectivity for CB2, and A-796,260 was found to be a highly selective CB2 agonist with little affinity for CB1, having a CB2 Ki of 4.6 nM vs 945 nM at CB1. [1] It has potent analgesic and anti-inflammatory actions in animal models, being especially effective in models of neuropathic pain, but without producing cannabis-like behavioral effects. [2]
As of October 2015 A-796,260 is a controlled substance in China. [3]
Legal status | |
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Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.233.198 |
Chemical and physical data | |
Formula | C22H30N2O2 |
Molar mass | 354.494 g·mol−1 |
3D model ( JSmol) | |
| |
| |
(what is this?) (verify) |
A-796,260 is a drug developed by Abbott Laboratories that acts as a potent and selective cannabinoid CB2 receptor agonist. Replacing the aromatic 3- benzoyl or 3- naphthoyl group found in most indole derived cannabinoids with the 3- tetramethyl cyclopropyl methanone group, imparts significant selectivity for CB2, and A-796,260 was found to be a highly selective CB2 agonist with little affinity for CB1, having a CB2 Ki of 4.6 nM vs 945 nM at CB1. [1] It has potent analgesic and anti-inflammatory actions in animal models, being especially effective in models of neuropathic pain, but without producing cannabis-like behavioral effects. [2]
As of October 2015 A-796,260 is a controlled substance in China. [3]