CP-93129 is a drug which acts as a potent and selective
serotonin5-HT1Breceptoragonist, with approximately 150x and 200x selectivity over the closely related 5-HT1D and 5-HT1A receptors.[1] It is used in the study of 5-HT1B receptors in the brain, particularly their role in modulating the release of other
neurotransmitters.[2][3][4][5]
References
^Macor JE, Burkhart CA, Heym JH, Ives JL, Lebel LA, Newman ME, et al. (August 1990). "3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole". Journal of Medicinal Chemistry. 33 (8): 2087–93.
doi:
10.1021/jm00170a007.
PMID2374139.
^De Groote L, Olivier B, Westenberg HG (August 2003). "Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice". European Journal of Pharmacology. 476 (1–2): 71–7.
doi:
10.1016/s0014-2999(03)02154-x.
PMID12969751.
^Przegaliński E, Papla I, Siwanowicz J, Filip M (May 2004). "Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats". European Neuropsychopharmacology. 14 (3): 217–25.
doi:
10.1016/S0924-977X(03)00106-8.
PMID15056481.
S2CID308992.
^Saitow F, Murano M, Suzuki H (March 2009). "Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei". Journal of Neurophysiology. 101 (3): 1361–74.
doi:
10.1152/jn.90750.2008.
PMID19144744.
CP-93129 is a drug which acts as a potent and selective
serotonin5-HT1Breceptoragonist, with approximately 150x and 200x selectivity over the closely related 5-HT1D and 5-HT1A receptors.[1] It is used in the study of 5-HT1B receptors in the brain, particularly their role in modulating the release of other
neurotransmitters.[2][3][4][5]
References
^Macor JE, Burkhart CA, Heym JH, Ives JL, Lebel LA, Newman ME, et al. (August 1990). "3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole". Journal of Medicinal Chemistry. 33 (8): 2087–93.
doi:
10.1021/jm00170a007.
PMID2374139.
^De Groote L, Olivier B, Westenberg HG (August 2003). "Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice". European Journal of Pharmacology. 476 (1–2): 71–7.
doi:
10.1016/s0014-2999(03)02154-x.
PMID12969751.
^Przegaliński E, Papla I, Siwanowicz J, Filip M (May 2004). "Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats". European Neuropsychopharmacology. 14 (3): 217–25.
doi:
10.1016/S0924-977X(03)00106-8.
PMID15056481.
S2CID308992.
^Saitow F, Murano M, Suzuki H (March 2009). "Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei". Journal of Neurophysiology. 101 (3): 1361–74.
doi:
10.1152/jn.90750.2008.
PMID19144744.