This article is missing information about some key characteristics that differentiate 5-HT1 as a whole from other 5-HT subtypes. Please expand the article to include this information. Further details may exist on the
talk page.(February 2017)
The 5-HT1 receptors are a subfamily of the 5-HT
serotonin receptors that bind to the
endogenousneurotransmitterserotonin (also known as 5-hydroxytryptamine, or 5-HT).[1] The 5-HT1 subfamily consists of five
G protein-coupled receptors (GPCRs) that share 40% to 63% overall sequence homology, including
5-HT1A,
5-HT1B,
5-HT1D,
5-HT1E, and
5-HT1F.[2] Receptors of the 5-HT1 type, specifically, the 5-HT1A and 5-HT1D receptor subtypes, are present on the cell bodies. Receptors of the 5-HT1 type, specifically, the 5-HT1B and 5-HT1D receptor subtypes, are also present on the nerve terminals. These receptors are broadly distributed throughout the brain and are recognized to play a significant part in regulating synaptic levels of 5-HT.[3]
The receptor subfamily is coupled to
Gi/Go and mediate
inhibitoryneurotransmission by inhibiting the function of adenylate cyclase and modulating downstream ionic effects.[4] This R-coupling to
Gi/Go proteins leads to a reduction in local concentrations of cAMP, proving that 5-HT1 are primarily inhibitory.[5] There is no 5-HT1C receptor, as it was reclassified as the
5-HT2C receptor.[6] For more information, please see the respective main articles of the individual subtypes:
This article is missing information about some key characteristics that differentiate 5-HT1 as a whole from other 5-HT subtypes. Please expand the article to include this information. Further details may exist on the
talk page.(February 2017)
The 5-HT1 receptors are a subfamily of the 5-HT
serotonin receptors that bind to the
endogenousneurotransmitterserotonin (also known as 5-hydroxytryptamine, or 5-HT).[1] The 5-HT1 subfamily consists of five
G protein-coupled receptors (GPCRs) that share 40% to 63% overall sequence homology, including
5-HT1A,
5-HT1B,
5-HT1D,
5-HT1E, and
5-HT1F.[2] Receptors of the 5-HT1 type, specifically, the 5-HT1A and 5-HT1D receptor subtypes, are present on the cell bodies. Receptors of the 5-HT1 type, specifically, the 5-HT1B and 5-HT1D receptor subtypes, are also present on the nerve terminals. These receptors are broadly distributed throughout the brain and are recognized to play a significant part in regulating synaptic levels of 5-HT.[3]
The receptor subfamily is coupled to
Gi/Go and mediate
inhibitoryneurotransmission by inhibiting the function of adenylate cyclase and modulating downstream ionic effects.[4] This R-coupling to
Gi/Go proteins leads to a reduction in local concentrations of cAMP, proving that 5-HT1 are primarily inhibitory.[5] There is no 5-HT1C receptor, as it was reclassified as the
5-HT2C receptor.[6] For more information, please see the respective main articles of the individual subtypes: