From Wikipedia, the free encyclopedia
MAS1
Identifiers
Aliases MAS1, MAS1 proto-oncogene, G protein-coupled receptor, MAS, MGRA
External IDs OMIM: 165180; MGI: 96918; HomoloGene: 1782; GeneCards: MAS1; OMA: MAS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002377
NM_001366704

NM_008552

RefSeq (protein)

NP_002368
NP_001353633

NP_032578

Location (UCSC) Chr 6: 159.89 – 159.92 Mb Chr 17: 13.06 – 13.09 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA, MAS, MGRA""), is a protein that in humans is encoded by the MAS1 gene. [5] The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects. [5]

Agonists of the receptor include angiotensin-(1-7). Antagonist include A-779 (angiotensin-1-7 with c-terminal proline substituted for D-Ala), or D-Pro (angiotensin-1-7 with c-terminal proline submitted for D-proline).

Mas1 proto-oncogene (MAS1, MGRA) is not to be confused with the MAS-related G-protein coupled receptor, a recently believed to be activated by the ligand alamandine (generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7)).

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130368Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068037Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MAS1 MAS1 oncogene".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

From Wikipedia, the free encyclopedia
MAS1
Identifiers
Aliases MAS1, MAS1 proto-oncogene, G protein-coupled receptor, MAS, MGRA
External IDs OMIM: 165180; MGI: 96918; HomoloGene: 1782; GeneCards: MAS1; OMA: MAS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002377
NM_001366704

NM_008552

RefSeq (protein)

NP_002368
NP_001353633

NP_032578

Location (UCSC) Chr 6: 159.89 – 159.92 Mb Chr 17: 13.06 – 13.09 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA, MAS, MGRA""), is a protein that in humans is encoded by the MAS1 gene. [5] The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects. [5]

Agonists of the receptor include angiotensin-(1-7). Antagonist include A-779 (angiotensin-1-7 with c-terminal proline substituted for D-Ala), or D-Pro (angiotensin-1-7 with c-terminal proline submitted for D-proline).

Mas1 proto-oncogene (MAS1, MGRA) is not to be confused with the MAS-related G-protein coupled receptor, a recently believed to be activated by the ligand alamandine (generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7)).

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130368Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068037Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MAS1 MAS1 oncogene".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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