MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA, MAS, MGRA""), is a protein that in humans is encoded by the MAS1 gene. [5] The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects. [5]
Agonists of the receptor include angiotensin-(1-7). Antagonist include A-779 (angiotensin-1-7 with c-terminal proline substituted for D-Ala), or D-Pro (angiotensin-1-7 with c-terminal proline submitted for D-proline).
Mas1 proto-oncogene (MAS1, MGRA) is not to be confused with the MAS-related G-protein coupled receptor, a recently believed to be activated by the ligand alamandine (generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7)).
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
MAS1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | MAS1, MAS1 proto-oncogene, G protein-coupled receptor, MAS, MGRA | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 165180; MGI: 96918; HomoloGene: 1782; GeneCards: MAS1; OMA: MAS1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA, MAS, MGRA""), is a protein that in humans is encoded by the MAS1 gene. [5] The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects. [5]
Agonists of the receptor include angiotensin-(1-7). Antagonist include A-779 (angiotensin-1-7 with c-terminal proline substituted for D-Ala), or D-Pro (angiotensin-1-7 with c-terminal proline submitted for D-proline).
Mas1 proto-oncogene (MAS1, MGRA) is not to be confused with the MAS-related G-protein coupled receptor, a recently believed to be activated by the ligand alamandine (generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7)).
This article incorporates text from the United States National Library of Medicine, which is in the public domain.