G protein-coupled receptor 50 is a
protein which in humans is encoded by the GPR50gene.[5][6][7]
Function
GPR50 is a member of the
G protein-coupled receptor family of
integral membrane proteins and is most closely related to the
melatonin receptor.[6] GPR50 is able to heterodimerize with both the
MT1 and
MT2 melatonin receptor subtypes. While GPR50 has no effect on MT2 function, GPR50 prevented MT1 from both binding
melatonin and coupling to
G proteins.[8] GPR50 is the mammalian ortholog of melatonin receptor Mel1c described in non-mammalian vertebrates.
[9]
^Gubitz AK, Reppert SM (January 1999). "Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)". Genomics. 55 (2): 248–51.
doi:
10.1006/geno.1998.5661.
PMID9933574.
Gubitz AK, Reppert SM (1999). "Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)". Genomics. 55 (2): 248–51.
doi:
10.1006/geno.1998.5661.
PMID9933574.
G protein-coupled receptor 50 is a
protein which in humans is encoded by the GPR50gene.[5][6][7]
Function
GPR50 is a member of the
G protein-coupled receptor family of
integral membrane proteins and is most closely related to the
melatonin receptor.[6] GPR50 is able to heterodimerize with both the
MT1 and
MT2 melatonin receptor subtypes. While GPR50 has no effect on MT2 function, GPR50 prevented MT1 from both binding
melatonin and coupling to
G proteins.[8] GPR50 is the mammalian ortholog of melatonin receptor Mel1c described in non-mammalian vertebrates.
[9]
^Gubitz AK, Reppert SM (January 1999). "Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)". Genomics. 55 (2): 248–51.
doi:
10.1006/geno.1998.5661.
PMID9933574.
Gubitz AK, Reppert SM (1999). "Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)". Genomics. 55 (2): 248–51.
doi:
10.1006/geno.1998.5661.
PMID9933574.