The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an
α2 adrenergic receptor, and also denotes the
human gene encoding it.[5]
Receptor
α2 adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. These receptors have a critical role in regulating
neurotransmitter release from
sympathetic nerves and from adrenergic neurons in the
central nervous system. Studies in mice revealed that both the α2A and α2C subtypes were required for normal
presynaptic control of transmitter release from sympathetic nerves in the
heart and from central noradrenergic neurons; the α2A subtype inhibited transmitter release at high stimulation frequencies, whereas the α2C subtype modulated neurotransmission at lower levels of nerve activity[6]
"α2A-adrenoceptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from
the original on 2015-04-02. Retrieved 2008-11-25.
Perälä M, Hirvonen H, Kalimo H, Ala-Uotila S, Regan JW, Akerman KE, Scheinin M (Nov 1992). "Differential expression of two alpha 2-adrenergic receptor subtype mRNAs in human tissues". Brain Research. Molecular Brain Research. 16 (1–2): 57–63.
doi:
10.1016/0169-328X(92)90193-F.
PMID1334200.
Surprenant A, Horstman DA, Akbarali H, Limbird LE (Aug 1992). "A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents". Science. 257 (5072): 977–80.
Bibcode:
1992Sci...257..977S.
doi:
10.1126/science.1354394.
PMID1354394.
Wang CD, Buck MA, Fraser CM (Aug 1991). "Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists". Molecular Pharmacology. 40 (2): 168–79.
PMID1678850.
Shilo L, Sakaue M, Thomas JM, Philip M, Hoffman BB (Jan 1994). "Enhanced transcription of the human alpha 2A-adrenergic receptor gene by cAMP: evidence for multiple cAMP responsive sequences in the promoter region of this gene". Cellular Signalling. 6 (1): 73–82.
doi:
10.1016/0898-6568(94)90062-0.
PMID8011430.
The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an
α2 adrenergic receptor, and also denotes the
human gene encoding it.[5]
Receptor
α2 adrenergic receptors include 3 highly homologous subtypes: α2A, α2B, and α2C. These receptors have a critical role in regulating
neurotransmitter release from
sympathetic nerves and from adrenergic neurons in the
central nervous system. Studies in mice revealed that both the α2A and α2C subtypes were required for normal
presynaptic control of transmitter release from sympathetic nerves in the
heart and from central noradrenergic neurons; the α2A subtype inhibited transmitter release at high stimulation frequencies, whereas the α2C subtype modulated neurotransmission at lower levels of nerve activity[6]
"α2A-adrenoceptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from
the original on 2015-04-02. Retrieved 2008-11-25.
Perälä M, Hirvonen H, Kalimo H, Ala-Uotila S, Regan JW, Akerman KE, Scheinin M (Nov 1992). "Differential expression of two alpha 2-adrenergic receptor subtype mRNAs in human tissues". Brain Research. Molecular Brain Research. 16 (1–2): 57–63.
doi:
10.1016/0169-328X(92)90193-F.
PMID1334200.
Surprenant A, Horstman DA, Akbarali H, Limbird LE (Aug 1992). "A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents". Science. 257 (5072): 977–80.
Bibcode:
1992Sci...257..977S.
doi:
10.1126/science.1354394.
PMID1354394.
Wang CD, Buck MA, Fraser CM (Aug 1991). "Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists". Molecular Pharmacology. 40 (2): 168–79.
PMID1678850.
Shilo L, Sakaue M, Thomas JM, Philip M, Hoffman BB (Jan 1994). "Enhanced transcription of the human alpha 2A-adrenergic receptor gene by cAMP: evidence for multiple cAMP responsive sequences in the promoter region of this gene". Cellular Signalling. 6 (1): 73–82.
doi:
10.1016/0898-6568(94)90062-0.
PMID8011430.