The G protein-coupled bile acid receptor 1 (GPBAR1) also known as G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or Takeda G protein-coupled receptor 5 (TGR5) is a
protein that in humans is encoded by the GPBAR1gene.[5][6]
Function
This gene encodes a member of the
G protein-coupled receptor (GPCR) superfamily. This protein functions as a cell surface receptor for
bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular
cAMP, activation of a
MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of
macrophage functions and regulation of energy homeostasis by bile acids.[7]
^Wang H, Tan YZ, Mu RH, Tang SS, Liu X, Xing SY, Long Y, Yuan DH, Hong H (June 2021). "Takeda G Protein-Coupled Receptor 5 Modulates Depression-like Behaviors via Hippocampal CA3 Pyramidal Neurons Afferent to Dorsolateral Septum". Biological Psychiatry. 89 (11): 1084–1095.
doi:
10.1016/j.biopsych.2020.11.018.
PMID33536132.
S2CID227165118.
Yasuda H, Hirata S, Inoue K, et al. (2007). "Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells". Biochem. Biophys. Res. Commun. 354 (1): 154–9.
doi:
10.1016/j.bbrc.2006.12.168.
PMID17214962.
"Bile Acid Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from
the original on 2016-03-03. Retrieved 2007-11-01.
The G protein-coupled bile acid receptor 1 (GPBAR1) also known as G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or Takeda G protein-coupled receptor 5 (TGR5) is a
protein that in humans is encoded by the GPBAR1gene.[5][6]
Function
This gene encodes a member of the
G protein-coupled receptor (GPCR) superfamily. This protein functions as a cell surface receptor for
bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular
cAMP, activation of a
MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of
macrophage functions and regulation of energy homeostasis by bile acids.[7]
^Wang H, Tan YZ, Mu RH, Tang SS, Liu X, Xing SY, Long Y, Yuan DH, Hong H (June 2021). "Takeda G Protein-Coupled Receptor 5 Modulates Depression-like Behaviors via Hippocampal CA3 Pyramidal Neurons Afferent to Dorsolateral Septum". Biological Psychiatry. 89 (11): 1084–1095.
doi:
10.1016/j.biopsych.2020.11.018.
PMID33536132.
S2CID227165118.
Yasuda H, Hirata S, Inoue K, et al. (2007). "Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells". Biochem. Biophys. Res. Commun. 354 (1): 154–9.
doi:
10.1016/j.bbrc.2006.12.168.
PMID17214962.
"Bile Acid Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from
the original on 2016-03-03. Retrieved 2007-11-01.