SDZ SER-082 is a drug which acts as a mixed
antagonist for the
5-HT2B and
5-HT2Cserotoninreceptors, with good selectivity over other
serotonin receptor subtypes and slight preference for 5-HT2C over 5-HT2B.[1] It has been used in animal studies into the behavioural effects of the different 5-HT2 subtypes,[2][3][4] and how they influence the effects of other drugs such as
cocaine.[5][6][7]
^Mora PO, Netto CF, Graeff FG (December 1997). "Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze". Pharmacology Biochemistry and Behavior. 58 (4): 1051–7.
doi:
10.1016/S0091-3057(97)00057-9.
PMID9408213.
S2CID11115355.
^Dave KD, Harvey JA, Aloyo VJ (May 2002). "A novel behavioral model that discriminates between 5-HT2A and 5-HT2C receptor activation". Pharmacology Biochemistry and Behavior. 72 (1–2): 371–8.
doi:
10.1016/S0091-3057(01)00767-5.
PMID11900808.
S2CID36921090.
^Hawkins MF, Uzelac SM, Hearn JK, Baumeister AA (October 2008). "Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat". Pharmacology Biochemistry and Behavior. 90 (4): 632–9.
doi:
10.1016/j.pbb.2008.05.006.
PMID18572227.
S2CID25959070.
^Filip M, Bubar MJ, Cunningham KA (September 2004). "Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses". The Journal of Pharmacology and Experimental Therapeutics. 310 (3): 1246–54.
doi:
10.1124/jpet.104.068841.
PMID15131246.
S2CID25809734.
^Filip M (2005). "Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats". Pharmacological Reports. 57 (1): 35–46.
PMID15849375.
^Filip M, Bubar MJ, Cunningham KA (January 2006). "Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats". Psychopharmacology. 183 (4): 482–9.
doi:
10.1007/s00213-005-0197-y.
PMID16261316.
S2CID23148827.
SDZ SER-082 is a drug which acts as a mixed
antagonist for the
5-HT2B and
5-HT2Cserotoninreceptors, with good selectivity over other
serotonin receptor subtypes and slight preference for 5-HT2C over 5-HT2B.[1] It has been used in animal studies into the behavioural effects of the different 5-HT2 subtypes,[2][3][4] and how they influence the effects of other drugs such as
cocaine.[5][6][7]
^Mora PO, Netto CF, Graeff FG (December 1997). "Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze". Pharmacology Biochemistry and Behavior. 58 (4): 1051–7.
doi:
10.1016/S0091-3057(97)00057-9.
PMID9408213.
S2CID11115355.
^Dave KD, Harvey JA, Aloyo VJ (May 2002). "A novel behavioral model that discriminates between 5-HT2A and 5-HT2C receptor activation". Pharmacology Biochemistry and Behavior. 72 (1–2): 371–8.
doi:
10.1016/S0091-3057(01)00767-5.
PMID11900808.
S2CID36921090.
^Hawkins MF, Uzelac SM, Hearn JK, Baumeister AA (October 2008). "Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat". Pharmacology Biochemistry and Behavior. 90 (4): 632–9.
doi:
10.1016/j.pbb.2008.05.006.
PMID18572227.
S2CID25959070.
^Filip M, Bubar MJ, Cunningham KA (September 2004). "Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses". The Journal of Pharmacology and Experimental Therapeutics. 310 (3): 1246–54.
doi:
10.1124/jpet.104.068841.
PMID15131246.
S2CID25809734.
^Filip M (2005). "Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats". Pharmacological Reports. 57 (1): 35–46.
PMID15849375.
^Filip M, Bubar MJ, Cunningham KA (January 2006). "Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats". Psychopharmacology. 183 (4): 482–9.
doi:
10.1007/s00213-005-0197-y.
PMID16261316.
S2CID23148827.