Clinical data | |
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Routes of administration | Oral, Rectal |
Legal status | |
Legal status |
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CAS Number | |
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ChemSpider | |
UNII | |
Chemical and physical data | |
Formula | C20H25NO |
Molar mass | 295.426 g·mol−1 |
3D model ( JSmol) | |
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Methoxphenidine (methoxydiphenidine, 2-MeO-Diphenidine, MXP) is a dissociative of the diarylethylamine class that has been sold online as a designer drug. [1] [2] Methoxphenidine was first reported in a 1989 patent where it was tested as a treatment for neurotoxic injury. [3] Shortly after the 2013 UK ban on arylcyclohexylamines methoxphenidine and the related compound diphenidine became available on the gray market, where it has been encountered as a powder and in tablet form. [4] Though diphenidine possesses higher affinity for the NMDA receptor, anecdotal reports suggest methoxphenidine has greater oral potency. [1] Of the three isomeric anisyl-substituents methoxphenidine has affinity for the NMDA receptor that is higher than 4-MeO-Diphenidine but lower than 3-MeO-Diphenidine, [3] [5] a structure–activity relationship shared by the arylcyclohexylamines. [6]
Acute methoxphenidine intoxication has been reported to produce confusion, hypertension, and tachycardia that was responsive to treatment with intravenous lorazepam, [7] [8] methoxphenidine has also been associated with three published fatalities [9] and one case of impaired driving. [10]
Psychotic episodes have also been reported, including a murder in June 2014. [11]
As of October 2015 MXP is a controlled substance in China. [12]
MXP is also banned in Sweden. [13]
In Canada, MT-45 and its analogues were made Schedule I controlled substances, which includes DPD[ clarification needed] in its structural group. [14] Possession without legal authority can result in maximum seven years imprisonment. Further, Health Canada amended the Food and Drug Regulations in May, 2016 to classify explicitly DPD as a restricted drug. Only those with a law enforcement agency, person with an exemption permit or institutions with Minister's authorization may possess the drug.
Clinical data | |
---|---|
Routes of administration | Oral, Rectal |
Legal status | |
Legal status |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
Chemical and physical data | |
Formula | C20H25NO |
Molar mass | 295.426 g·mol−1 |
3D model ( JSmol) | |
| |
|
Methoxphenidine (methoxydiphenidine, 2-MeO-Diphenidine, MXP) is a dissociative of the diarylethylamine class that has been sold online as a designer drug. [1] [2] Methoxphenidine was first reported in a 1989 patent where it was tested as a treatment for neurotoxic injury. [3] Shortly after the 2013 UK ban on arylcyclohexylamines methoxphenidine and the related compound diphenidine became available on the gray market, where it has been encountered as a powder and in tablet form. [4] Though diphenidine possesses higher affinity for the NMDA receptor, anecdotal reports suggest methoxphenidine has greater oral potency. [1] Of the three isomeric anisyl-substituents methoxphenidine has affinity for the NMDA receptor that is higher than 4-MeO-Diphenidine but lower than 3-MeO-Diphenidine, [3] [5] a structure–activity relationship shared by the arylcyclohexylamines. [6]
Acute methoxphenidine intoxication has been reported to produce confusion, hypertension, and tachycardia that was responsive to treatment with intravenous lorazepam, [7] [8] methoxphenidine has also been associated with three published fatalities [9] and one case of impaired driving. [10]
Psychotic episodes have also been reported, including a murder in June 2014. [11]
As of October 2015 MXP is a controlled substance in China. [12]
MXP is also banned in Sweden. [13]
In Canada, MT-45 and its analogues were made Schedule I controlled substances, which includes DPD[ clarification needed] in its structural group. [14] Possession without legal authority can result in maximum seven years imprisonment. Further, Health Canada amended the Food and Drug Regulations in May, 2016 to classify explicitly DPD as a restricted drug. Only those with a law enforcement agency, person with an exemption permit or institutions with Minister's authorization may possess the drug.