Combination of | |
---|---|
Netupitant | NK1 receptor antagonist |
Palonosetron | 5-HT3 receptor antagonist |
Clinical data | |
Trade names | Akynzeo |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a614053 |
License data | |
Pregnancy category |
|
Routes of administration | By mouth, intravenous |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
CAS Number | |
KEGG |
Netupitant/palonosetron, sold under the brand name Akynzeo, is a fixed-dose combination medication used for the prevention of acute and delayed chemotherapy-induced nausea and vomiting. [7] [9] It is marketed and distributed by Helsinn Therapeutics. Netupitant is an NK1 receptor antagonist and palonosetron is a 5-HT3 receptor antagonist. [10]
The capsules contain netupitant and palonosetron hydrochloride. The intravenous version is a combination of fosnetupitant chloride hydrochloride and palonosetron hydrochloride. [11] [7] [8]
Netupitant/palonosetron may be contraindicated during pregnancy. [12] [1] [13]
The most common side effects include headache, weakness, fatigue, upset stomach, constipation, and skin redness. [7] The overall profile of adverse effects is comparable to that of palonosetron (see Palonosetron#Adverse effects); no common adverse effects can be attributed to netupitant. [12]
Netupitant/palonosetron was approved for use in the United States in October 2014. [14] It was approved for use in the European Union in May 2015. [8] The intravenous version, which contains the prodrug fosnetupitant in place of netupitant, was approved in the United States in April 2018. [15] [11]
{{
cite web}}
: CS1 maint: archived copy as title (
link)
Combination of | |
---|---|
Netupitant | NK1 receptor antagonist |
Palonosetron | 5-HT3 receptor antagonist |
Clinical data | |
Trade names | Akynzeo |
AHFS/ Drugs.com | Monograph |
MedlinePlus | a614053 |
License data | |
Pregnancy category |
|
Routes of administration | By mouth, intravenous |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
CAS Number | |
KEGG |
Netupitant/palonosetron, sold under the brand name Akynzeo, is a fixed-dose combination medication used for the prevention of acute and delayed chemotherapy-induced nausea and vomiting. [7] [9] It is marketed and distributed by Helsinn Therapeutics. Netupitant is an NK1 receptor antagonist and palonosetron is a 5-HT3 receptor antagonist. [10]
The capsules contain netupitant and palonosetron hydrochloride. The intravenous version is a combination of fosnetupitant chloride hydrochloride and palonosetron hydrochloride. [11] [7] [8]
Netupitant/palonosetron may be contraindicated during pregnancy. [12] [1] [13]
The most common side effects include headache, weakness, fatigue, upset stomach, constipation, and skin redness. [7] The overall profile of adverse effects is comparable to that of palonosetron (see Palonosetron#Adverse effects); no common adverse effects can be attributed to netupitant. [12]
Netupitant/palonosetron was approved for use in the United States in October 2014. [14] It was approved for use in the European Union in May 2015. [8] The intravenous version, which contains the prodrug fosnetupitant in place of netupitant, was approved in the United States in April 2018. [15] [11]
{{
cite web}}
: CS1 maint: archived copy as title (
link)