From Wikipedia, the free encyclopedia
CVL-354
Clinical data
Routes of
administration
Oral administration
Drug class Opioid antagonist; κ-Opioid receptor antagonist

CVL-354 is an opioid antagonist which is under development for the treatment of major depressive disorder and substance-related disorders. [1] [2]

It acts as a selective antagonist of the κ-opioid receptor. [1] [2] The drug is also more weakly an antagonist of the μ-opioid receptor, with about 31-fold lower affinity and 27-fold lower inhibitory potency at the μ-opioid receptor relative to the κ-opioid receptor. [2] CVL-354 is taken by mouth. [1] It was originated by Pfizer and is under development by Cerevel Therapeutics. [1] As of September 2022, CVL-354 is in phase 1 clinical trials for major depressive disorder and is in the preclincal stage of development for substance-related disorders. [1]

See also

References

  1. ^ a b c d e "CVL 354 – Cerevel therapeutics". Adis Insight. Springer Nature Switzerland AG.
  2. ^ a b c "ACNP 61st Annual Meeting: Poster Abstracts P271-P540". Neuropsychopharmacology. 47 (Suppl 1): 220–370. December 2022. doi: 10.1038/s41386-022-01485-0. eISSN  1740-634X. PMC  9714399. PMID  36456694.


From Wikipedia, the free encyclopedia
CVL-354
Clinical data
Routes of
administration
Oral administration
Drug class Opioid antagonist; κ-Opioid receptor antagonist

CVL-354 is an opioid antagonist which is under development for the treatment of major depressive disorder and substance-related disorders. [1] [2]

It acts as a selective antagonist of the κ-opioid receptor. [1] [2] The drug is also more weakly an antagonist of the μ-opioid receptor, with about 31-fold lower affinity and 27-fold lower inhibitory potency at the μ-opioid receptor relative to the κ-opioid receptor. [2] CVL-354 is taken by mouth. [1] It was originated by Pfizer and is under development by Cerevel Therapeutics. [1] As of September 2022, CVL-354 is in phase 1 clinical trials for major depressive disorder and is in the preclincal stage of development for substance-related disorders. [1]

See also

References

  1. ^ a b c d e "CVL 354 – Cerevel therapeutics". Adis Insight. Springer Nature Switzerland AG.
  2. ^ a b c "ACNP 61st Annual Meeting: Poster Abstracts P271-P540". Neuropsychopharmacology. 47 (Suppl 1): 220–370. December 2022. doi: 10.1038/s41386-022-01485-0. eISSN  1740-634X. PMC  9714399. PMID  36456694.



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