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ATC code |
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CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.131.532 |
Chemical and physical data | |
Formula | C21H38N4O8 |
Molar mass | 474.555 g·mol−1 |
3D model ( JSmol) | |
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Amastatin, also known as 3-amino-2-hydroxy-5-methylhexanoyl-L-valyl-L-valyl-L-aspartic acid, is a naturally occurring, competitive and reversible aminopeptidase inhibitor that was isolated from Streptomyces sp. ME 98-M3. [1] It specifically inhibits leucyl aminopeptidase, alanyl aminopeptidase (aminopeptidase M/N), bacterial leucyl aminopeptidase (Aeromonas proteolytica aminopeptidase), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), [2] and, to a lesser extent, glutamyl aminopeptidase (aminopeptidase A), [3] as well as other aminopeptidases. [4] It does not inhibit arginyl aminopeptidase (aminopeptidase B). [5] [6] Amastatin has been found to potentiate the central nervous system effects of oxytocin and vasopressin in vivo. [7] It also inhibits the degradation of met-enkephalin, dynorphin A, and other endogenous peptides. [8]
Clinical data | |
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ATC code |
|
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
KEGG | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.131.532 |
Chemical and physical data | |
Formula | C21H38N4O8 |
Molar mass | 474.555 g·mol−1 |
3D model ( JSmol) | |
| |
|
Amastatin, also known as 3-amino-2-hydroxy-5-methylhexanoyl-L-valyl-L-valyl-L-aspartic acid, is a naturally occurring, competitive and reversible aminopeptidase inhibitor that was isolated from Streptomyces sp. ME 98-M3. [1] It specifically inhibits leucyl aminopeptidase, alanyl aminopeptidase (aminopeptidase M/N), bacterial leucyl aminopeptidase (Aeromonas proteolytica aminopeptidase), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), [2] and, to a lesser extent, glutamyl aminopeptidase (aminopeptidase A), [3] as well as other aminopeptidases. [4] It does not inhibit arginyl aminopeptidase (aminopeptidase B). [5] [6] Amastatin has been found to potentiate the central nervous system effects of oxytocin and vasopressin in vivo. [7] It also inhibits the degradation of met-enkephalin, dynorphin A, and other endogenous peptides. [8]