From Wikipedia, the free encyclopedia
FAUC50
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Names
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Preferred IUPAC name
5-[(1R)-2-{[2-(4-{3-[(2-Aminoethyl)disulfanyl]propoxy}-3-methoxyphenyl)ethyl]amino}-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one
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Identifiers
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ChemSpider
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UNII
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InChI=1S/C25H33N3O5S2/c1-32-23-15-17(3-7-22(23)33-12-2-13-34-35-14-10-26)9-11-27-16-21(30)18-4-6-20(29)25-19(18)5-8-24(31)28-25/h3-8,15,21,27,29-30H,2,9-14,16,26H2,1H3,(H,28,31)/t21-/m0/s1 Key: MQROXSOVKCABJV-NRFANRHFSA-N
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O=C1NC2=C(C([C@@H](O)CNCCC3=CC=C(OCCCSSCCN)C(OC)=C3)=CC=C2O)C=C1
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Properties
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C25H33N3O5S2
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Molar mass
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519.67 g·mol−1
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
FAUC50 is a
covalent agonist of the
β2 adrenoceptor.
[1] It has been used as a template to form covalent agonists for other receptors.
[2]
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^ Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK (January 2011).
"Structure and function of an irreversible agonist-β(2) adrenoceptor complex". Nature. 469 (7329): 236–40.
Bibcode:
2011Natur.469..236R.
doi:
10.1038/nature09665.
PMC
3074335.
PMID
21228876.
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^ Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hübner H, Kobilka BK, Gmeiner P (July 2014).
"Covalent agonists for studying G protein-coupled receptor activation". Proceedings of the National Academy of Sciences of the United States of America. 111 (29): 10744–8.
Bibcode:
2014PNAS..11110744W.
doi:
10.1073/pnas.1410415111.
PMC
4115510.
PMID
25006259.
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α1 | Agonists | |
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Antagonists |
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Abanoquil
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Ajmalicine
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Alfuzosin
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Anisodamine
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Anisodine
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Atiprosin
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Atypical antipsychotics (e.g.,
brexpiprazole,
clozapine,
olanzapine,
quetiapine,
risperidone)
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Benoxathian
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Beta blockers (e.g.,
adimolol,
amosulalol,
arotinolol,
carvedilol,
eugenodilol,
labetalol)
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Buflomedil
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Bunazosin
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Corynanthine
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Dapiprazole
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Domesticine
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Doxazosin
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Ergolines (e.g.,
acetergamine,
ergotamine,
dihydroergotamine,
lisuride,
nicergoline,
terguride)
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Etoperidone
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Fenspiride
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Hydroxyzine
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Indoramin
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Ketanserin
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L-765,314
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mCPP
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Mepiprazole
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Metazosin
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Monatepil
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Moxisylyte
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Naftopidil
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Nantenine
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Neldazosin
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Niaprazine
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Niguldipine
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Pardoprunox
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Pelanserin
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Perlapine
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Phendioxan
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Phenoxybenzamine
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Phentolamine
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Phenylpiperazine
antidepressants (e.g.,
hydroxynefazodone,
nefazodone,
trazodone,
triazoledione)
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Piperoxan
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Prazosin
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Quinazosin
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Quinidine
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Silodosin
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Spegatrine
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Spiperone
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Talipexole
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Tamsulosin
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Terazosin
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Tiodazosin
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Tolazoline
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Tetracyclic antidepressants (e.g.,
amoxapine,
maprotiline,
mianserin)
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Tricyclic antidepressants (e.g.,
amitriptyline,
clomipramine,
doxepin,
imipramine,
trimipramine)
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Trimazosin
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Typical antipsychotics (e.g.,
chlorpromazine,
fluphenazine,
loxapine,
thioridazine)
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Urapidil
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WB-4101
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Zolertine
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α2 | Agonists | |
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Antagonists |
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1-PP
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Adimolol
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Amesergide
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Aptazapine
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Atipamezole
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Atypical antipsychotics (e.g.,
asenapine,
brexpiprazole,
clozapine,
lurasidone,
olanzapine,
paliperidone,
quetiapine,
risperidone,
zotepine)
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Azapirones (e.g.,
buspirone,
gepirone,
ipsapirone,
tandospirone)
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BRL-44408
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Buflomedil
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Cirazoline
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Efaroxan
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Esmirtazapine
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Fenmetozole
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Fluparoxan
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Idazoxan
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Ketanserin
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Lisuride
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mCPP
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Mianserin
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Mirtazapine
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NAN-190
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Pardoprunox
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Phentolamine
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Phenoxybenzamine
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Piperoxan
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Piribedil
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Rauwolscine
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Rotigotine
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Setiptiline
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Spegatrine
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Spiroxatrine
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Sunepitron
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Terguride
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Tolazoline
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Typical antipsychotics (e.g.,
chlorpromazine,
fluphenazine,
loxapine,
thioridazine)
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Yohimbine
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β | |
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