From Wikipedia, the free encyclopedia
(Redirected from
Empatic)
Combination drug
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| Combination of | |
|---|---|
| Bupropion | Norepinephrine-dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist |
| Zonisamide | Sulfonamide anticonvulsant |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | |
| (verify) | |
Bupropion/zonisamide (former tentative brand name Empatic, Excalia) is an experimental combination of bupropion which was under development for the treatment of obesity. [1] [2] [3] Bupropion is a norepinephrine–dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist, while zonisamide is an anticonvulsant acting as a sodium channel blocker, T-type calcium channel blocker, and weak carbonic anhydrase inhibitor. [1] The combination was being developed by Orexigen Therapeutics and reached phase II clinical trials prior to discontinuation. [1] [4] [5]
- ^ a b c "Bupropion/Zonisamide - AdisInsight".
- ^ "Empatic Shows Long-Term Weight Loss, Improved Quality Of Life Contrave(R) Reduces Rate Of Metabolic Syndrome By Half". Archived from the original on 2010-01-11. Retrieved 2010-01-07.
- ^ Empatic Obesity Drug Information and News
- ^ Ioannides-Demos LL, Piccenna L, McNeil JJ (2011). "Pharmacotherapies for obesity: past, current, and future therapies" (PDF). Journal of Obesity. 2011: 179674. doi: 10.1155/2011/179674. PMC 3006492. PMID 21197148.
- ^ Adan RA (February 2013). "Mechanisms underlying current and future anti-obesity drugs". Trends in Neurosciences. 36 (2): 133–40. doi: 10.1016/j.tins.2012.12.001. PMID 23312373. S2CID 21974224.
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DATTooltip Dopamine transporter ( DRIsTooltip Dopamine reuptake inhibitors) |
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NETTooltip Norepinephrine transporter ( NRIsTooltip Norepinephrine reuptake inhibitors) |
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SERTTooltip Serotonin transporter ( SRIsTooltip Serotonin reuptake inhibitors) |
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| VMATsTooltip Vesicular monoamine transporters | |||||||||||||||
| Others |
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| nAChRsTooltip Nicotinic acetylcholine receptors |
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Precursors (and prodrugs) | |||||
 | This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |
Retrieved from "
https://en.wikipedia.org/?title=Bupropion/zonisamide&oldid=1187871260"
Hidden categories:
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From Wikipedia, the free encyclopedia
(Redirected from
Empatic)
Combination drug
|
| |
| Combination of | |
|---|---|
| Bupropion | Norepinephrine-dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist |
| Zonisamide | Sulfonamide anticonvulsant |
| Legal status | |
| Legal status |
|
| Identifiers | |
| CAS Number | |
| (verify) | |
Bupropion/zonisamide (former tentative brand name Empatic, Excalia) is an experimental combination of bupropion which was under development for the treatment of obesity. [1] [2] [3] Bupropion is a norepinephrine–dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist, while zonisamide is an anticonvulsant acting as a sodium channel blocker, T-type calcium channel blocker, and weak carbonic anhydrase inhibitor. [1] The combination was being developed by Orexigen Therapeutics and reached phase II clinical trials prior to discontinuation. [1] [4] [5]
- ^ a b c "Bupropion/Zonisamide - AdisInsight".
- ^ "Empatic Shows Long-Term Weight Loss, Improved Quality Of Life Contrave(R) Reduces Rate Of Metabolic Syndrome By Half". Archived from the original on 2010-01-11. Retrieved 2010-01-07.
- ^ Empatic Obesity Drug Information and News
- ^ Ioannides-Demos LL, Piccenna L, McNeil JJ (2011). "Pharmacotherapies for obesity: past, current, and future therapies" (PDF). Journal of Obesity. 2011: 179674. doi: 10.1155/2011/179674. PMC 3006492. PMID 21197148.
- ^ Adan RA (February 2013). "Mechanisms underlying current and future anti-obesity drugs". Trends in Neurosciences. 36 (2): 133–40. doi: 10.1016/j.tins.2012.12.001. PMID 23312373. S2CID 21974224.
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| Others |
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DATTooltip Dopamine transporter ( DRIsTooltip Dopamine reuptake inhibitors) |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
NETTooltip Norepinephrine transporter ( NRIsTooltip Norepinephrine reuptake inhibitors) |
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SERTTooltip Serotonin transporter ( SRIsTooltip Serotonin reuptake inhibitors) |
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| VMATsTooltip Vesicular monoamine transporters | |||||||||||||||
| Others |
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| nAChRsTooltip Nicotinic acetylcholine receptors |
| ||||
|---|---|---|---|---|---|
|
Precursors (and prodrugs) | |||||
|
| This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |
Retrieved from "
https://en.wikipedia.org/?title=Bupropion/zonisamide&oldid=1187871260"
Hidden categories:
- Articles with short description
- Short description matches Wikidata
- Drugs with non-standard legal status
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs missing an ATC code
- Drugs that are a combination of chemicals
- All stub articles