Zinc finger and BTB domain-containing protein 16 is a
protein that in humans is encoded by the ZBTB16gene.
Function
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a
zinc fingertranscription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in
cell cycle progression, and interacts with a
histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with
acute promyelocytic leukemia (APL)[5] and physiological roles have been identified in mouse
Natural Killer T cells[6][7] and
gamma-delta T cells.[8] Alternate transcriptional splice variants have been characterized in human.[9][10]
Interactions
Zinc finger and BTB domain-containing protein 16 has been shown to
interact with:
^Dhordain P, Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The HD, Zelent A, Koken MH (2000). "Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF". Oncogene. 19 (54): 6240–50.
doi:
10.1038/sj.onc.1203976.
PMID11175338.
S2CID23619694.
^
abcdChauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A (2004). "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". Oncogene. 23 (54): 8777–84.
doi:
10.1038/sj.onc.1208128.
PMID15467736.
S2CID26092755.
^
abcDavid G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56.
doi:
10.1038/sj.onc.1202043.
PMID9627120.
S2CID655636.
^Nanba D, Toki F, Higashiyama S (2004). "Roles of charged amino acid residues in the cytoplasmic domain of proHB-EGF". Biochem. Biophys. Res. Commun. 320 (2): 376–82.
doi:
10.1016/j.bbrc.2004.05.176.
PMID15219838.
^Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD (2000). "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood. 96 (12): 3939–47.
doi:
10.1182/blood.V96.12.3939.
PMID11090081.
^Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, et al. (1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47.
doi:
10.1182/blood.V94.11.3737.
PMID10572087.
David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56.
doi:
10.1038/sj.onc.1202043.
PMID9627120.
S2CID655636.
van Schothorst EM, Prins DE, Baysal BE, Beekman M, Licht JD, Waxman S, Zelent A, Cornelisse CJ, et al. (1999). "Genomic structure of the human PLZF gene". Gene. 236 (1): 21–4.
doi:
10.1016/S0378-1119(99)00277-2.
PMID10433962.
Li X, Peng H, Schultz DC, Lopez-Guisa JM, Rauscher FJ, Marmorstein R (1999). "Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein". Cancer Research. 59 (20): 5275–82.
PMID10537309.
Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, et al. (1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47.
doi:
10.1182/blood.V94.11.3737.
PMID10572087.
Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD (2000). "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood. 96 (12): 3939–47.
doi:
10.1182/blood.V96.12.3939.
PMID11090081.
Zinc finger and BTB domain-containing protein 16 is a
protein that in humans is encoded by the ZBTB16gene.
Function
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a
zinc fingertranscription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in
cell cycle progression, and interacts with a
histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with
acute promyelocytic leukemia (APL)[5] and physiological roles have been identified in mouse
Natural Killer T cells[6][7] and
gamma-delta T cells.[8] Alternate transcriptional splice variants have been characterized in human.[9][10]
Interactions
Zinc finger and BTB domain-containing protein 16 has been shown to
interact with:
^Dhordain P, Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The HD, Zelent A, Koken MH (2000). "Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF". Oncogene. 19 (54): 6240–50.
doi:
10.1038/sj.onc.1203976.
PMID11175338.
S2CID23619694.
^
abcdChauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A (2004). "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". Oncogene. 23 (54): 8777–84.
doi:
10.1038/sj.onc.1208128.
PMID15467736.
S2CID26092755.
^
abcDavid G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56.
doi:
10.1038/sj.onc.1202043.
PMID9627120.
S2CID655636.
^Nanba D, Toki F, Higashiyama S (2004). "Roles of charged amino acid residues in the cytoplasmic domain of proHB-EGF". Biochem. Biophys. Res. Commun. 320 (2): 376–82.
doi:
10.1016/j.bbrc.2004.05.176.
PMID15219838.
^Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD (2000). "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood. 96 (12): 3939–47.
doi:
10.1182/blood.V96.12.3939.
PMID11090081.
^Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, et al. (1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47.
doi:
10.1182/blood.V94.11.3737.
PMID10572087.
David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56.
doi:
10.1038/sj.onc.1202043.
PMID9627120.
S2CID655636.
van Schothorst EM, Prins DE, Baysal BE, Beekman M, Licht JD, Waxman S, Zelent A, Cornelisse CJ, et al. (1999). "Genomic structure of the human PLZF gene". Gene. 236 (1): 21–4.
doi:
10.1016/S0378-1119(99)00277-2.
PMID10433962.
Li X, Peng H, Schultz DC, Lopez-Guisa JM, Rauscher FJ, Marmorstein R (1999). "Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein". Cancer Research. 59 (20): 5275–82.
PMID10537309.
Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, et al. (1999). "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47.
doi:
10.1182/blood.V94.11.3737.
PMID10572087.
Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD (2000). "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood. 96 (12): 3939–47.
doi:
10.1182/blood.V96.12.3939.
PMID11090081.