From Wikipedia, the free encyclopedia
Protein found in humans
Pre-B-cell leukemia transcription factor 3 is a
protein that in humans is encoded by the PBX3
gene.
[5]
[6]
References
Further reading
- Lu Q, Wright DD, Kamps MP (1994).
"Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation". Mol. Cell. Biol. 14 (6): 3938–48.
doi:
10.1128/mcb.14.6.3938.
PMC
358760.
PMID
7910944.
- Shen WF, Rozenfeld S, Kwong A, et al. (1999).
"HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells". Mol. Cell. Biol. 19 (4): 3051–61.
doi:
10.1128/mcb.19.4.3051.
PMC
84099.
PMID
10082572.
- Fujino T, Yamazaki Y, Largaespada DA, et al. (2001).
"Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Exp. Hematol. 29 (7): 856–63.
doi:
10.1016/S0301-472X(01)00655-5.
PMID
11438208.
- Knoepfler PS, Sykes DB, Pasillas M, Kamps MP (2001).
"HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation". Oncogene. 20 (39): 5440–8.
doi:
10.1038/sj.onc.1204710.
PMID
11571641.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5.
doi:
10.1038/ng1285.
PMID
14702039.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004).
"DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74.
Bibcode:
2004Natur.429..369H.
doi:
10.1038/nature02465.
PMC
2734081.
PMID
15164053.
- Rhee JW, Arata A, Selleri L, et al. (2004).
"Pbx3 Deficiency Results in Central Hypoventilation". Am. J. Pathol. 165 (4): 1343–50.
doi:
10.1016/S0002-9440(10)63392-5.
PMC
1618620.
PMID
15466398.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
doi:
10.1101/gr.2596504.
PMC
528928.
PMID
15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8.
Bibcode:
2005Natur.437.1173R.
doi:
10.1038/nature04209.
PMID
16189514.
S2CID
4427026.
External links
PDB gallery |
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1b72: PBX1, HOMEOBOX PROTEIN HOX-B1/DNA TERNARY COMPLEX
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1b8i: STRUCTURE OF THE HOMEOTIC UBX/EXD/DNA TERNARY COMPLEX
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1du6: SOLUTION STRUCTURE OF THE TRUNCATED PBX HOMEODOMAIN
-
1lfu: NMR solution structure of the extended PBX homeodomain bound to DNA
-
1puf: Crystal structure of HoxA9 and Pbx1 homeodomains bound to DNA
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(1) Basic domains |
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(1.1) Basic
leucine zipper (
bZIP) | |
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(1.2) Basic helix-loop-helix (
bHLH) | Group A | |
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Group B | |
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Group C bHLH-
PAS | |
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Group D | |
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Group E | |
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Group F bHLH-COE | |
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(1.3)
bHLH-ZIP | |
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(1.4) NF-1 | |
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(1.5) RF-X | |
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(1.6) Basic helix-span-helix (bHSH) | |
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(2)
Zinc finger DNA-binding domains |
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(2.1)
Nuclear receptor (Cys4) | subfamily 1 | |
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subfamily 2 | |
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subfamily 3 | |
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subfamily 4 | |
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subfamily 5 | |
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subfamily 6 | |
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subfamily 0 | |
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(2.2) Other Cys4 | |
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(2.3) Cys2His2 | |
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(2.4) Cys6 | |
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(2.5) Alternating composition | |
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(2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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This article incorporates text from the
United States National Library of Medicine, which is in the
public domain.