From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Zinc finger and BTB domain-containing protein 7A is a
protein that in humans is encoded by the ZBTB7A
gene.
[5]
[6]
[7]
Interactions
ZBTB7A has been shown to
interact with
BCL6.
[8]
See also
References
- ^
a
b
c
GRCh38: Ensembl release 89: ENSG00000178951 –
Ensembl, May 2017
- ^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000035011 –
Ensembl, May 2017
-
^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^ Morrison DJ, Pendergrast PS, Stavropoulos P, Colmenares SU, Kobayashi R, Hernandez N (Apr 1999).
"FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein". Nucleic Acids Res. 27 (5): 1251–62.
doi:
10.1093/nar/27.5.1251.
PMC
148309.
PMID
9973611.
-
^ Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (Feb 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene. 18 (2): 365–75.
doi:
10.1038/sj.onc.1202332.
PMID
9927193.
S2CID
5769828.
-
^
"Entrez Gene: ZBTB7A zinc finger and BTB domain containing 7A".
-
^ Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (January 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene. 18 (2): 365–75.
doi:
10.1038/sj.onc.1202332.
PMID
9927193.
S2CID
5769828.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997).
"Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806.
doi:
10.1101/gr.6.9.791.
PMID
8889548.
- Pendergrast PS, Wang C, Hernandez N, Huang S (2002).
"FBI-1 Can Stimulate HIV-1 Tat Activity and Is Targeted to a Novel Subnuclear Domain that Includes the Tat-P-TEFb—containing Nuclear Speckles". Mol. Biol. Cell. 13 (3): 915–29.
doi:
10.1091/mbc.01-08-0383.
PMC
99609.
PMID
11907272.
- Lee DK, Suh D, Edenberg HJ, Hur MW (2002).
"POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1". J. Biol. Chem. 277 (30): 26761–8.
doi:
10.1074/jbc.M202078200.
PMID
12004059.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.
- Pessler F, Hernandez N (2003).
"Flexible DNA binding of the BTB/POZ-domain protein FBI-1". J. Biol. Chem. 278 (31): 29327–35.
doi:
10.1074/jbc.M302980200.
PMID
12750370.
- Laudes M, Christodoulides C, Sewter C, et al. (2004).
"Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis". J. Biol. Chem. 279 (12): 11711–8.
doi:
10.1074/jbc.M310240200.
PMC
4303998.
PMID
14701838.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5.
Bibcode:
2004PNAS..10112130B.
doi:
10.1073/pnas.0404720101.
PMC
514446.
PMID
15302935.
- Liu CJ, Prazak L, Fajardo M, et al. (2004).
"Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis". J. Biol. Chem. 279 (45): 47081–91.
doi:
10.1074/jbc.M405288200.
PMID
15337766.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
doi:
10.1101/gr.2596504.
PMC
528928.
PMID
15489334.
- Maeda T, Hobbs RM, Merghoub T, et al. (2005). "Role of the proto-oncogene Pokémon in cellular transformation and ARF repression". Nature. 433 (7023): 278–85.
Bibcode:
2005Natur.433..278M.
doi:
10.1038/nature03203.
PMID
15662416.
S2CID
4308742.
- Lee DK, Kang JE, Park HJ, et al. (2005).
"FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB". J. Biol. Chem. 280 (30): 27783–91.
doi:
10.1074/jbc.M504909200.
PMID
15917220.
- Olsen JV, Blagoev B, Gnad F, et al. (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48.
doi:
10.1016/j.cell.2006.09.026.
PMID
17081983.
S2CID
7827573.
- Roh HE, Lee MN, Jeon BN, et al. (2007).
"Regulation of Pokémon 1 activity by sumoylation". Cell. Physiol. Biochem. 20 (1–4): 167–80.
doi:
10.1159/000104164.
PMID
17595526.
External links
PDB gallery |
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2if5: Structure of the POZ domain of human LRF, a master regulator of oncogenesis
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2nn2: Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator
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(1) Basic domains |
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(1.1) Basic
leucine zipper (
bZIP) | |
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(1.2) Basic helix-loop-helix (
bHLH) | Group A | |
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Group B | |
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Group C bHLH-
PAS | |
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Group D | |
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Group E | |
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Group F bHLH-COE | |
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(1.3)
bHLH-ZIP | |
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(1.4) NF-1 | |
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(1.5) RF-X | |
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(1.6) Basic helix-span-helix (bHSH) | |
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(2)
Zinc finger DNA-binding domains |
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(2.1)
Nuclear receptor (Cys4) | subfamily 1 | |
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subfamily 2 | |
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subfamily 3 | |
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subfamily 4 | |
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subfamily 5 | |
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subfamily 6 | |
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subfamily 0 | |
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(2.2) Other Cys4 | |
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(2.3) Cys2His2 | |
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(2.4) Cys6 | |
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(2.5) Alternating composition | |
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(2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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This article incorporates text from the
United States National Library of Medicine, which is in the
public domain.