Octamer transcription factors are a family of transcription factors which binds to the "ATTTGCAT" DNA sequence. [1] Their DNA-binding domain is a POU domain.
There are eight Octamer proteins in humans (Oct1–11), [2] which have been renamed according to the different classes of POU domain. [3] Octamer-3/4, also known as POU5F1, is one of the Yamanaka factors, which are critical for the maintenance and self-renewal of embryonic stem cells. [3] On the other hand, Oct-1 and Oct-2 are widely expressed in adult tissues. [3] Oct-7, 8 and 9, also known as "brain factors", are predominantly expressed in the central nervous system during embryonic development. [3] Oct-6 expression is confined to embryonic stem cells and the developing nervous system and skin, while Oct-11 is also involved in skin differentiation. [3]
Octamer transcription factors are a family of transcription factors which binds to the "ATTTGCAT" DNA sequence. [1] Their DNA-binding domain is a POU domain.
There are eight Octamer proteins in humans (Oct1–11), [2] which have been renamed according to the different classes of POU domain. [3] Octamer-3/4, also known as POU5F1, is one of the Yamanaka factors, which are critical for the maintenance and self-renewal of embryonic stem cells. [3] On the other hand, Oct-1 and Oct-2 are widely expressed in adult tissues. [3] Oct-7, 8 and 9, also known as "brain factors", are predominantly expressed in the central nervous system during embryonic development. [3] Oct-6 expression is confined to embryonic stem cells and the developing nervous system and skin, while Oct-11 is also involved in skin differentiation. [3]