PHF1

PHF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E5P, 2M0O, 4HCZ
Identifiers
Aliases	PHF1, MTF2L2, PCL1, PHF2, TDRD19C, hPHD finger protein 1
External IDs	OMIM: 602881; MGI: 98647; HomoloGene: 7567; GeneCards: PHF1; OMA: PHF1 - orthologs
Gene location ( Human)
Chr.	Chromosome 6 (human)
End	33,416,453 bp
Gene location ( Mouse)
Chr.	Chromosome 17 (mouse)
End	27,156,882 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; pituitary gland; ; anterior pituitary; ; left ovary; ; right ovary; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; canal of the cervix; ; gastric mucosa;
	Top expressed in
	granulocyte; ; zygote; ; spermatocyte; ; secondary oocyte; ; primary oocyte; ; spermatid; ; neural layer of retina; ; ankle joint; ; seminiferous tubule; ; entorhinal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; metal ion binding; methylated histone binding; protein binding; chromatin binding; nucleosome binding; sequence-specific DNA binding;
Cellular component	cytoplasm; site of double-strand break; ESC/E(Z) complex; nucleoplasm; microtubule organizing center; cytoskeleton; nucleus; centrosome;
Biological process	negative regulation of histone H3-K27 methylation; regulation of transcription, DNA-templated; transcription, DNA-templated; cellular response to DNA damage stimulus; regulation of histone methylation; negative regulation of gene expression, epigenetic; positive regulation of histone H3-K27 methylation; chromatin organization; positive regulation of transcription, DNA-templated;
	Sources: Amigo / QuickGO
Orthologs
	5252
	21652
	ENSG00000112511; ENSG00000225553; ENSG00000239756
	ENSMUSG00000024193
	O43189
	Q9Z1B8
	NM_002636; NM_024165
	NM_009343; NM_001302397
	NP_002627; NP_077084
	NP_001289326; NP_033369
	Wikidata
View/Edit Human	View/Edit Mouse

PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene.^[5]^[6]^[7]

Function

This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.^[7]

References

^ ^a ^b ^c ENSG00000225553, ENSG00000239756 GRCh38: Ensembl release 89: ENSG00000112511, ENSG00000225553, ENSG00000239756 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024193 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Coulson M, Robert S, Eyre HJ, Saint R (March 1998). "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster". Genomics. 48 (3): 381–3. doi: 10.1006/geno.1997.5201. PMID 9545646.
^ Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A (May 2008). "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell". Nucleic Acids Research. 36 (9): 2939–47. doi: 10.1093/nar/gkn146. PMC 2396414. PMID 18385154.
^ ^a ^b "Entrez Gene: PHF1 PHD finger protein 1".

External links

PHF1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000225553, ENSG00000239756 GRCh38: Ensembl release 89: ENSG00000112511, ENSG00000225553, ENSG00000239756 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024193 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9545646-5] Coulson M, Robert S, Eyre HJ, Saint R (March 1998). "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster". Genomics. 48 (3): 381–3. doi: 10.1006/geno.1997.5201. PMID 9545646.

[pmid18385154-6] Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A (May 2008). "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell". Nucleic Acids Research. 36 (9): 2939–47. doi: 10.1093/nar/gkn146. PMC 2396414. PMID 18385154.

[entrez-7] "Entrez Gene: PHF1 PHD finger protein 1".

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Function

References

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