Krueppel-like factor 5 is a
protein that in humans is encoded by the KLF5gene.[5][6]
Function
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a
transcription factor.[6]
Kojima S, Kobayashi A, Gotoh O, Ohkuma Y, Fujii-Kuriyama Y, Sogawa K (Feb 1997). "Transcriptional activation domain of human BTEB2, a GC box-binding factor". Journal of Biochemistry. 121 (2): 389–96.
doi:
10.1093/oxfordjournals.jbchem.a021600.
PMID9089417.
Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sata M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R (Aug 2002). "Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling". Nature Medicine. 8 (8): 856–63.
doi:
10.1038/nm738.
PMID12101409.
S2CID34181151.
Sur I, Undén AB, Toftgård R (Jun 2002). "Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles". European Journal of Cell Biology. 81 (6): 323–34.
doi:
10.1078/0171-9335-00257.
PMID12113473.
Ohnishi S, Ohnami S, Laub F, Aoki K, Suzuki K, Kanai Y, Haga K, Asaka M, Ramirez F, Yoshida T (Aug 2003). "Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer". Biochemical and Biophysical Research Communications. 308 (2): 251–6.
doi:
10.1016/S0006-291X(03)01356-1.
PMID12901861.
Krueppel-like factor 5 is a
protein that in humans is encoded by the KLF5gene.[5][6]
Function
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a
transcription factor.[6]
Kojima S, Kobayashi A, Gotoh O, Ohkuma Y, Fujii-Kuriyama Y, Sogawa K (Feb 1997). "Transcriptional activation domain of human BTEB2, a GC box-binding factor". Journal of Biochemistry. 121 (2): 389–96.
doi:
10.1093/oxfordjournals.jbchem.a021600.
PMID9089417.
Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sata M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R (Aug 2002). "Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling". Nature Medicine. 8 (8): 856–63.
doi:
10.1038/nm738.
PMID12101409.
S2CID34181151.
Sur I, Undén AB, Toftgård R (Jun 2002). "Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles". European Journal of Cell Biology. 81 (6): 323–34.
doi:
10.1078/0171-9335-00257.
PMID12113473.
Ohnishi S, Ohnami S, Laub F, Aoki K, Suzuki K, Kanai Y, Haga K, Asaka M, Ramirez F, Yoshida T (Aug 2003). "Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer". Biochemical and Biophysical Research Communications. 308 (2): 251–6.
doi:
10.1016/S0006-291X(03)01356-1.
PMID12901861.