GTF2F1

GTF2F1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F3U, 1I27, 1J2X, 1NHA, 1ONV, 2K7L, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	GTF2F1, general transcription factor IIF, polypeptide 1, 74kDa, BTF4, RAP74, TF2F1, TFIIF, general transcription factor IIF subunit 1
External IDs	OMIM: 189968; MGI: 1923848; HomoloGene: 1585; GeneCards: GTF2F1; OMA: GTF2F1 - orthologs
Gene location ( Human)
Chr.	Chromosome 19 (human)
End	6,393,981 bp
Gene location ( Mouse)
Chr.	Chromosome 17 (mouse)
End	57,318,288 bp
RNA expression pattern
	Top expressed in
	cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; left testis; ; right hemisphere of cerebellum; ; right testis; ; left ovary; ; prefrontal cortex; ; anterior pituitary; ; superior frontal gyrus;
	Top expressed in
	saccule; ; otic placode; ; otic vesicle; ; seminiferous tubule; ; neural layer of retina; ; tail of embryo; ; primitive streak; ; primary oocyte; ; yolk sac; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; transcription factor binding; protein binding; phosphatase activator activity; RNA binding; protein phosphatase binding; protein domain specific binding; RNA polymerase II general transcription initiation factor activity; promoter-specific chromatin binding;
Cellular component	intracellular membrane-bounded organelle; nucleoplasm; transcription factor TFIIF complex; cell junction; transcription factor TFIID complex; nucleus; protein-containing complex;
Biological process	mRNA splicing, via spliceosome; regulation of transcription, DNA-templated; transcription elongation from RNA polymerase II promoter; response to virus; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of viral transcription; transcription initiation from RNA polymerase II promoter; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; snRNA transcription by RNA polymerase II; fibroblast growth factor receptor signaling pathway; positive regulation of catalytic activity; RNA metabolic process; negative regulation of protein binding;
	Sources: Amigo / QuickGO
Orthologs
	2962
	98053
	ENSG00000125651
	ENSMUSG00000002658
	P35269
	Q3THK3
	NM_002096
	NM_133801
	NP_002087
	NP_598562
	Wikidata
View/Edit Human	View/Edit Mouse

General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.^[5]^[6]

Interactions

GTF2F1 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125651 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002658 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (March 1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature. 355 (6359): 464–7. Bibcode: 1992Natur.355..464F. doi: 10.1038/355464a0. PMID 1734284. S2CID 1241044.
^ "Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa".
^ Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. 273 (42): 27593–601. doi: 10.1074/jbc.273.42.27593. PMID 9765293.
^ ^a ^b ^c ^d ^e ^f Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode: 1997PNAS...94.5605S. doi: 10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.
^ Kim MK, Nikodem VM (October 1999). "hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation". Mol. Cell. Biol. 19 (10): 6833–44. doi: 10.1128/MCB.19.10.6833. PMC 84680. PMID 10490622.
^ Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. doi: 10.1128/MCB.17.10.6029. PMC 232452. PMID 9315662.
^ Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (September 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. doi: 10.1128/MCB.18.9.5355. PMC 109120. PMID 9710619.
^ Joliot V, Demma M, Prywes R (February 1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor". Nature. 373 (6515): 632–5. Bibcode: 1995Natur.373..632J. doi: 10.1038/373632a0. PMID 7854423. S2CID 47196160.
^ Zhu H, Joliot V, Prywes R (February 1994). "Role of transcription factor TFIIF in serum response factor-activated transcription". J. Biol. Chem. 269 (5): 3489–97. doi: 10.1016/S0021-9258(17)41889-8. PMID 8106390.
^ Dikstein R, Ruppert S, Tjian R (March 1996). "TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74". Cell. 84 (5): 781–90. doi: 10.1016/s0092-8674(00)81055-7. PMID 8625415. S2CID 18490534.
^ ^a ^b Ruppert S, Tjian R (November 1995). "Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation". Genes Dev. 9 (22): 2747–55. doi: 10.1101/gad.9.22.2747. PMID 7590250.
^ Siegert JL, Robbins PD (January 1999). "Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250". Mol. Cell. Biol. 19 (1): 846–54. doi: 10.1128/MCB.19.1.846. PMC 83941. PMID 9858607.
^ ^a ^b Malik S, Guermah M, Roeder RG (March 1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. Bibcode: 1998PNAS...95.2192M. doi: 10.1073/pnas.95.5.2192. PMC 19292. PMID 9482861.
^ Fang SM, Burton ZF (May 1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding". J. Biol. Chem. 271 (20): 11703–9. doi: 10.1074/jbc.271.20.11703. PMID 8662660.

External links

GTF2F1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
FactorBook GTF2F1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125651 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002658 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1734284-5] Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF (March 1992). "A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II". Nature. 355 (6359): 464–7. Bibcode: 1992Natur.355..464F. doi: 10.1038/355464a0. PMID 1734284. S2CID 1241044.

[entrez-6] "Entrez Gene: GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa".

[pmid9765293-7] Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". J. Biol. Chem. 273 (42): 27593–601. doi: 10.1074/jbc.273.42.27593. PMID 9765293.

[pmid9159119-8] ^ ^a ^b ^c ^d ^e ^f Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5605–10. Bibcode: 1997PNAS...94.5605S. doi: 10.1073/pnas.94.11.5605. PMC 20825. PMID 9159119.

[pmid10490622-9] Kim MK, Nikodem VM (October 1999). "hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation". Mol. Cell. Biol. 19 (10): 6833–44. doi: 10.1128/MCB.19.10.6833. PMC 84680. PMID 10490622.

[pmid9315662-10] Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. doi: 10.1128/MCB.17.10.6029. PMC 232452. PMID 9315662.

[pmid9710619-11] Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D (September 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. 18 (9): 5355–63. doi: 10.1128/MCB.18.9.5355. PMC 109120. PMID 9710619.

[pmid7854423-12] Joliot V, Demma M, Prywes R (February 1995). "Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor". Nature. 373 (6515): 632–5. Bibcode: 1995Natur.373..632J. doi: 10.1038/373632a0. PMID 7854423. S2CID 47196160.

[pmid8106390-13] Zhu H, Joliot V, Prywes R (February 1994). "Role of transcription factor TFIIF in serum response factor-activated transcription". J. Biol. Chem. 269 (5): 3489–97. doi: 10.1016/S0021-9258(17)41889-8. PMID 8106390.

[pmid8625415-14] Dikstein R, Ruppert S, Tjian R (March 1996). "TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74". Cell. 84 (5): 781–90. doi: 10.1016/s0092-8674(00)81055-7. PMID 8625415. S2CID 18490534.

[pmid7590250-15] Ruppert S, Tjian R (November 1995). "Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation". Genes Dev. 9 (22): 2747–55. doi: 10.1101/gad.9.22.2747. PMID 7590250.

[pmid9858607-16] Siegert JL, Robbins PD (January 1999). "Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAFII250". Mol. Cell. Biol. 19 (1): 846–54. doi: 10.1128/MCB.19.1.846. PMC 83941. PMID 9858607.

[pmid9482861-17] Malik S, Guermah M, Roeder RG (March 1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. Bibcode: 1998PNAS...95.2192M. doi: 10.1073/pnas.95.5.2192. PMC 19292. PMID 9482861.

[pmid8662660-18] Fang SM, Burton ZF (May 1996). "RNA polymerase II-associated protein (RAP) 74 binds transcription factor (TF) IIB and blocks TFIIB-RAP30 binding". J. Biol. Chem. 271 (20): 11703–9. doi: 10.1074/jbc.271.20.11703. PMID 8662660.

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Interactions

See also

References

Further reading

External links

Interactions

See also

References

Further reading

External links

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