Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a
protein which in humans is encoded by the TFAP4
gene.[5]
Function
Transcription factor AP4 is a member of the
basic helix-loop-helix (bHLH)
transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.
Lewis TB, Wood S, Michaelis EK, et al. (1996). "Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24". Genomics. 32 (1): 131–3.
doi:
10.1006/geno.1996.0088.
PMID8786101.
King-Jones K, Korge G, Lehmann M (1999). "The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4". J. Mol. Biol. 291 (1): 71–82.
doi:
10.1006/jmbi.1999.2963.
PMID10438607.
Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a
protein which in humans is encoded by the TFAP4
gene.[5]
Function
Transcription factor AP4 is a member of the
basic helix-loop-helix (bHLH)
transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.
Lewis TB, Wood S, Michaelis EK, et al. (1996). "Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24". Genomics. 32 (1): 131–3.
doi:
10.1006/geno.1996.0088.
PMID8786101.
King-Jones K, Korge G, Lehmann M (1999). "The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4". J. Mol. Biol. 291 (1): 71–82.
doi:
10.1006/jmbi.1999.2963.
PMID10438607.