B3 DNA binding domain | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
![]() B3 DNA binding domain of RAV1 | |||||||||||
Identifiers | |||||||||||
Symbol | B3_domain | ||||||||||
Pfam | PF02362 | ||||||||||
InterPro | IPR003340 | ||||||||||
PROSITE | PS50863 | ||||||||||
SCOP2 | 1wid / SCOPe / SUPFAM | ||||||||||
CDD | cd10017 | ||||||||||
|
The B3 DNA binding domain (DBD) is a highly conserved domain found exclusively in transcription factors (≥40 species) ( Pfam PF02362) combined with other domains ( InterPro: IPR003340). It consists of 100-120 residues, includes seven beta strands and two alpha helices that form a DNA-binding pseudobarrel protein fold ( SCOP 117343); it interacts with the major groove of DNA. [1]
In Arabidopsis thaliana, there are three main families of transcription factors that contain B3 domain: [2]
protein | ARF1- B3 | ABI3- B3 | RAV1- B3 |
---|---|---|---|
B3 structure derived by | molecular model [1] | molecular model [1] | NMR [1] |
B3 recognition sequence | TGTCTC [3] [4] | CATGCA [5] [6] | CACCTG [7] |
PDB: 1WID [1] and PDB: 1YEL [8] are only known NMR solution phase structures of the B3 DNA Binding Domain.
The N-terminal domain of restriction endonuclease EcoRII; the C-terminal domain of restriction endonuclease BfiI possess a similar DNA-binding pseudobarrel protein fold. [9] [10]
B3 DNA binding domain | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
![]() B3 DNA binding domain of RAV1 | |||||||||||
Identifiers | |||||||||||
Symbol | B3_domain | ||||||||||
Pfam | PF02362 | ||||||||||
InterPro | IPR003340 | ||||||||||
PROSITE | PS50863 | ||||||||||
SCOP2 | 1wid / SCOPe / SUPFAM | ||||||||||
CDD | cd10017 | ||||||||||
|
The B3 DNA binding domain (DBD) is a highly conserved domain found exclusively in transcription factors (≥40 species) ( Pfam PF02362) combined with other domains ( InterPro: IPR003340). It consists of 100-120 residues, includes seven beta strands and two alpha helices that form a DNA-binding pseudobarrel protein fold ( SCOP 117343); it interacts with the major groove of DNA. [1]
In Arabidopsis thaliana, there are three main families of transcription factors that contain B3 domain: [2]
protein | ARF1- B3 | ABI3- B3 | RAV1- B3 |
---|---|---|---|
B3 structure derived by | molecular model [1] | molecular model [1] | NMR [1] |
B3 recognition sequence | TGTCTC [3] [4] | CATGCA [5] [6] | CACCTG [7] |
PDB: 1WID [1] and PDB: 1YEL [8] are only known NMR solution phase structures of the B3 DNA Binding Domain.
The N-terminal domain of restriction endonuclease EcoRII; the C-terminal domain of restriction endonuclease BfiI possess a similar DNA-binding pseudobarrel protein fold. [9] [10]