GTF3C1

GTF3C1
Identifiers
Aliases	GTF3C1, TFIIIC, TFIIIC220, TFIIICalpha, general transcription factor IIIC subunit 1
External IDs	OMIM: 603246; MGI: 107887; HomoloGene: 31040; GeneCards: GTF3C1; OMA: GTF3C1 - orthologs
Gene location ( Human)
Chr.	Chromosome 16 (human)
End	27,549,913 bp
Gene location ( Mouse)
Chr.	Chromosome 7 (mouse)
End	125,306,952 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; skin of leg; ; skin of abdomen; ; sural nerve; ; right lobe of thyroid gland; ; ventricular zone; ; left lobe of thyroid gland; ; right hemisphere of cerebellum; ; apex of heart; ; stromal cell of endometrium;
	Top expressed in
	tail of embryo; ; spermatocyte; ; genital tubercle; ; internal carotid artery; ; external carotid artery; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; superior frontal gyrus; ; ventricular zone; ; vestibular membrane of cochlear duct;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; RNA polymerase III general transcription initiation factor activity; RNA polymerase III type 1 promoter sequence-specific DNA binding; RNA polymerase III type 2 promoter sequence-specific DNA binding;
Cellular component	transcription factor TFIIIC complex; nucleolus; membrane; nucleus; nucleoplasm; ribonucleoprotein complex;
Biological process	tRNA transcription by RNA polymerase III; rRNA transcription; tRNA transcription; transcription, DNA-templated; transcription by RNA polymerase III; regulation of transcription by RNA polymerase III; transcription initiation from RNA polymerase III promoter; 5S class rRNA transcription by RNA polymerase III;
	Sources: Amigo / QuickGO
Orthologs
	2975
	233863
	ENSG00000077235
	ENSMUSG00000032777
	Q12789
	Q8K284
	NM_001286242; NM_001520
	NM_207239
	NP_001273171; NP_001511
	NP_997122
	Wikidata
View/Edit Human	View/Edit Mouse

General transcription factor 3C polypeptide 1 is a protein that in humans is encoded by the GTF3C1 gene.^[5]^[6]^[7]

Interactions

GTF3C1 has been shown to interact with GTF3C4.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077235 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032777 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lagna G, Kovelman R, Sukegawa J, Roeder RG (May 1994). "Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC". Mol. Cell. Biol. 14 (5): 3053–64. doi: 10.1128/mcb.14.5.3053. PMC 358673. PMID 8164661.
^ L'Etoile ND, Fahnestock ML, Shen Y, Aebersold R, Berk AJ (Apr 1994). "Human transcription factor IIIC box B binding subunit". Proc. Natl. Acad. Sci. U.S.A. 91 (5): 1652–6. Bibcode: 1994PNAS...91.1652L. doi: 10.1073/pnas.91.5.1652. PMC 43221. PMID 8127861.
^ "Entrez Gene: GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa".
^ Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi: 10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.

External links

GTF3C1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077235 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032777 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8164661-5] Lagna G, Kovelman R, Sukegawa J, Roeder RG (May 1994). "Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC". Mol. Cell. Biol. 14 (5): 3053–64. doi: 10.1128/mcb.14.5.3053. PMC 358673. PMID 8164661.

[pmid8127861-6] L'Etoile ND, Fahnestock ML, Shen Y, Aebersold R, Berk AJ (Apr 1994). "Human transcription factor IIIC box B binding subunit". Proc. Natl. Acad. Sci. U.S.A. 91 (5): 1652–6. Bibcode: 1994PNAS...91.1652L. doi: 10.1073/pnas.91.5.1652. PMC 43221. PMID 8127861.

[entrez-7] "Entrez Gene: GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa".

[pmid10523658-8] Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi: 10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.

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Interactions

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