From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
V-erbA-related protein 2 (EAR-2) also known as NR2F6 (nuclear receptor subfamily 2 group F member 6) is a
protein that in humans is encoded by the NR2F6
gene .
[5] V-erbA-related protein 2 is a member of the
nuclear receptor family of
intracellular
transcription factors . It is named after its similarity to v-erbA (
P03373 ), a helper of an oncoprotein called v-erbB in
avian erythroblastosis virus .
[6]
Function
Comparatively little is known about ear-2, but it has been shown to function as a
coregulator of other nuclear receptors.
[7]
[8]
Interactions
V-erbA-related gene has been shown to
interact with:
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000160113 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000002393 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T (December 1988).
"Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other" . Nucleic Acids Research . 16 (23): 11057–74.
doi :
10.1093/nar/16.23.11057 .
PMC
338996 .
PMID
2905047 .
^ Thormeyer, D; Baniahmad, A (October 1999). "The v-erbA oncogene (review)". International Journal of Molecular Medicine . 4 (4): 351–8.
PMID
10493974 .
^
a
b Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000).
"The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function" . Molecular and Cellular Biology . 20 (7): 2604–18.
doi :
10.1128/MCB.20.7.2604-2618.2000 .
PMC
85476 .
PMID
10713182 .
^ Liu X, Huang X, Sigmund CD (May 2003).
"Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription" . Circulation Research . 92 (9): 1033–40.
doi :
10.1161/01.RES.0000071355.82009.43 .
PMID
12690040 .
^ Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M (May 1999).
"Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2" . The Journal of Biological Chemistry . 274 (20): 14331–6.
doi :
10.1074/jbc.274.20.14331 .
PMC
2823254 .
PMID
10318855 .
Further reading
Bähler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS (July 1997). "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1". Genomics . 43 (1): 107–9.
doi :
10.1006/geno.1997.4776 .
PMID
9226381 .
Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M (May 1999).
"Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2" . The Journal of Biological Chemistry . 274 (20): 14331–6.
doi :
10.1074/jbc.274.20.14331 .
PMC
2823254 .
PMID
10318855 .
Zhang Y, Dufau ML (January 2000).
"Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor" . The Journal of Biological Chemistry . 275 (4): 2763–70.
doi :
10.1074/jbc.275.4.2763 .
PMID
10644740 .
Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000).
"The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function" . Molecular and Cellular Biology . 20 (7): 2604–18.
doi :
10.1128/MCB.20.7.2604-2618.2000 .
PMC
85476 .
PMID
10713182 .
Liu X, Huang X, Sigmund CD (May 2003).
"Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription" . Circulation Research . 92 (9): 1033–40.
doi :
10.1161/01.RES.0000071355.82009.43 .
PMID
12690040 .
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .
External links
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors