bZIP transcription factor | |||||||||
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Identifiers | |||||||||
Symbol | bZIP_1 | ||||||||
Pfam | PF00170 | ||||||||
InterPro | IPR011616 | ||||||||
PROSITE | PDOC00036 | ||||||||
SCOP2 | 1ysa / SCOPe / SUPFAM | ||||||||
CDD | cd14686 | ||||||||
Membranome | 235 | ||||||||
|
The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as arginine and lysine. Proteins containing this domain are transcription factors. [1] [2]
bZIP transcription factors are found in all eukaryotes and form one of the largest families of dimerizing TFs. [3] An evolutionary study from 2008 revealed that 4 bZIP genes were encoded by the genome of the most recent common ancestor of all plants. [4] Interactions between bZIP transcription factors are numerous and complex [5] [6] [3] and play important roles in cancer development [7] in epithelial tissues, steroid hormone synthesis by cells of endocrine tissues, [8] factors affecting reproductive functions, [9] and several other phenomena that affect human health.
ATF1; ATF2; ATF4; ATF5; ATF6; ATF7; BACH1; BACH2; BATF; BATF2; CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; CEBPZ; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREB5; CREBL1; CREM; E4BP4; FOSL1; FOSL2; JUN; JUNB; JUND; MAFA; MAFB; MAFF; MAFG; NRL; C-MAF; MAFK; NFE2; NFE2L2; NFE2L3; SNFT; XBP1
bZIP transcription factor | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
Symbol | bZIP_1 | ||||||||
Pfam | PF00170 | ||||||||
InterPro | IPR011616 | ||||||||
PROSITE | PDOC00036 | ||||||||
SCOP2 | 1ysa / SCOPe / SUPFAM | ||||||||
CDD | cd14686 | ||||||||
Membranome | 235 | ||||||||
|
The Basic Leucine Zipper Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as arginine and lysine. Proteins containing this domain are transcription factors. [1] [2]
bZIP transcription factors are found in all eukaryotes and form one of the largest families of dimerizing TFs. [3] An evolutionary study from 2008 revealed that 4 bZIP genes were encoded by the genome of the most recent common ancestor of all plants. [4] Interactions between bZIP transcription factors are numerous and complex [5] [6] [3] and play important roles in cancer development [7] in epithelial tissues, steroid hormone synthesis by cells of endocrine tissues, [8] factors affecting reproductive functions, [9] and several other phenomena that affect human health.
ATF1; ATF2; ATF4; ATF5; ATF6; ATF7; BACH1; BACH2; BATF; BATF2; CEBPA; CEBPB; CEBPD; CEBPE; CEBPG; CEBPZ; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREB5; CREBL1; CREM; E4BP4; FOSL1; FOSL2; JUN; JUNB; JUND; MAFA; MAFB; MAFF; MAFG; NRL; C-MAF; MAFK; NFE2; NFE2L2; NFE2L3; SNFT; XBP1