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Protein-coding gene in the species Homo sapiens
Early growth response protein 4 (EGR-4), also known as AT133 , is a
protein that in humans is encoded by the EGR4
gene .
[5]
EGR-4 is a member of the
early growth response (EGF) family of
zinc finger
transcription factors .
References
Further reading
Crosby SD, Veile RA, Donis-Keller H, et al. (1992).
"Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C" . Proc. Natl. Acad. Sci. U.S.A . 89 (10): 4739–43.
Bibcode :
1992PNAS...89.4739C .
doi :
10.1073/pnas.89.10.4739 .
PMC
49159 .
PMID
1584812 .
Hillier LW, Graves TA, Fulton RS, et al. (2005).
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4" . Nature . 434 (7034): 724–31.
Bibcode :
2005Natur.434..724H .
doi :
10.1038/nature03466 .
PMID
15815621 .
Müller HJ, Skerka C, Bialonski A, Zipfel PF (November 1991).
"Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains" . Proc. Natl. Acad. Sci. U.S.A . 88 (22): 10079–83.
Bibcode :
1991PNAS...8810079M .
doi :
10.1073/pnas.88.22.10079 .
PMC
52871 .
PMID
1658795 .
Decker EL, Nehmann N, Kampen E, et al. (2003).
"Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression" . Nucleic Acids Res . 31 (3): 911–21.
doi :
10.1093/nar/gkg186 .
PMC
149206 .
PMID
12560487 .
Liu BC, Zhang J, Wang L, et al. (2010). "No association between EGR gene family polymorphisms and schizophrenia in the Chinese population". Prog. Neuropsychopharmacol. Biol. Psychiatry . 34 (3): 506–9.
doi :
10.1016/j.pnpbp.2010.02.005 .
PMID
20144677 .
S2CID
207409159 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65.
doi :
10.1101/gr.4039406 .
PMC
1356129 .
PMID
16344560 .
Holst C, Skerka C, Lichter P, et al. (1993). "Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133". Hum. Mol. Genet . 2 (4): 367–72.
doi :
10.1093/hmg/2.4.367 .
PMID
8504297 .
Crosby SD, Puetz JJ, Simburger KS, et al. (1991).
"The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family" . Mol. Cell. Biol . 11 (8): 3835–41.
doi :
10.1128/MCB.11.8.3835 .
PMC
361165 .
PMID
2072895 .
Hadziselimovic F, Hadziselimovic NO, Demougin P, et al. (2009).
"EGR4 is a master gene responsible for fertility in cryptorchidism" . Sex Dev . 3 (5): 253–63.
doi :
10.1159/000249147 .
PMID
19828938 .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors