NFIA

NFIA
Identifiers
Aliases	NFIA, CTF, NF-I/A, NF1-A, NFI-A, NFI-L, nuclear factor I A, BRMUTD
External IDs	OMIM: 600727; MGI: 108056; HomoloGene: 4086; GeneCards: NFIA; OMA: NFIA - orthologs
Gene location ( Human)
Chr.	Chromosome 1 (human)
End	61,462,788 bp
Gene location ( Mouse)
Chr.	Chromosome 4 (mouse)
End	98,007,111 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; urethra; ; saphenous vein; ; vena cava; ; buccal mucosa cell; ; cardia; ; nipple; ; parietal pleura; ; endothelial cell; ; synovial joint;
	Top expressed in
	seminal vesicula; ; vestibular membrane of cochlear duct; ; vestibular sensory epithelium; ; external carotid artery; ; Rostral migratory stream; ; internal carotid artery; ; lobe of cerebellum; ; cerebellar vermis; ; atrioventricular valve; ; facial motor nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; chromatin binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cell junction; intracellular anatomical structure; nucleus; nucleoplasm;
Biological process	viral genome replication; DNA replication; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; synapse maturation; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; ureter development;
	Sources: Amigo / QuickGO
Orthologs
	4774
	18027
	ENSG00000162599
	ENSMUSG00000028565
	Q12857
	Q02780
	NM_001134673; NM_001145511; NM_001145512; NM_005595
	NM_001122952; NM_001122953; NM_010905
	NP_001128145; NP_001138983; NP_001138984; NP_005586
	NP_001116424; NP_001116425; NP_035035
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear factor 1 A-type is a protein that in humans is encoded by the NFIA gene.^[5]^[6]

Function

Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellular transcription factors and as replication factors for adenovirus DNA replication. Diversity in this protein family is generated by multiple genes, differential splicing, and heterodimerization.[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162599 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028565 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Qian F, Kruse U, Lichter P, Sippel AE (July 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi: 10.1006/geno.1995.1107. PMID 7590749.
^ ^a ^b "Entrez Gene: NFIA nuclear factor I/A".

Leahy P, Crawford DR, Grossman G, Gronostajski RM, Hanson RW (March 1999). "CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription". The Journal of Biological Chemistry. 274 (13): 8813–22. doi: 10.1074/jbc.274.13.8813. PMID 10085123.
das Neves L, Duchala CS, Tolentino-Silva F, Haxhiu MA, Colmenares C, Macklin WB, Campbell CE, Butz KG, Gronostajski RM, Godinho F (October 1999). "Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum". Proceedings of the National Academy of Sciences of the United States of America. 96 (21): 11946–51. Bibcode: 1999PNAS...9611946D. doi: 10.1073/pnas.96.21.11946. PMC 18392. PMID 10518556.
Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (February 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65. PMID 10718198.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode: 2004PNAS..10112130B. doi: 10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Xu H, Uno JK, Inouye M, Collins JF, Ghishan FK (February 2005). "NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene". American Journal of Physiology. Gastrointestinal and Liver Physiology. 288 (2): G175-81. doi: 10.1152/ajpgi.00396.2004. PMID 15458926. S2CID 14194207.
Wang W, Stock RE, Gronostajski RM, Wong YW, Schachner M, Kilpatrick DL (December 2004). "A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression". The Journal of Biological Chemistry. 279 (51): 53491–7. doi: 10.1074/jbc.M410370200. PMID 15466411.
Champ PC, Maurice S, Vargason JM, Camp T, Ho PS (2005). "Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation". Nucleic Acids Research. 32 (22): 6501–10. doi: 10.1093/nar/gkh988. PMC 545456. PMID 15598822.
Berry FB, O'Neill MA, Coca-Prados M, Walter MA (February 2005). "FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner". Molecular and Cellular Biology. 25 (4): 1415–24. doi: 10.1128/MCB.25.4.1415-1424.2005. PMC 548007. PMID 15684392.
Fazi F, Rosa A, Fatica A, Gelmetti V, De Marchis ML, Nervi C, Bozzoni I (December 2005). "A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis". Cell. 123 (5): 819–31. doi: 10.1016/j.cell.2005.09.023. PMID 16325577. S2CID 6003724.
Lin YL, Wang YH, Lee HJ (November 2006). "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A". Biochemical and Biophysical Research Communications. 350 (2): 430–6. doi: 10.1016/j.bbrc.2006.09.061. PMID 17010934.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Lu W, Quintero-Rivera F, Fan Y, Alkuraya FS, Donovan DJ, Xi Q, Turbe-Doan A, Li QG, Campbell CG, Shanske AL, Sherr EH, Ahmad A, Peters R, Rilliet B, Parvex P, Bassuk AG, Harris DJ, Ferguson H, Kelly C, Walsh CA, Gronostajski RM, Devriendt K, Higgins A, Ligon AH, Quade BJ, Morton CC, Gusella JF, Maas RL (May 2007). "NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects". PLOS Genetics. 3 (5): e80. doi: 10.1371/journal.pgen.0030080. PMC 1877820. PMID 17530927.

External links

NFIA+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162599 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028565 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7590749-5] Qian F, Kruse U, Lichter P, Sippel AE (July 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi: 10.1006/geno.1995.1107. PMID 7590749.

[entrez-6] "Entrez Gene: NFIA nuclear factor I/A".

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[2]

[3]

[4]

[5]

[6]

Function

References

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Function

References

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