MAX dimerization protein 3 is a
protein that in humans is encoded by the MXD3gene located on Chromosome 5.[5][6]
MXD3 is a
basic helix-loop-helix protein belonging to a subfamily of
MAX-interacting proteins. This protein competes with
MYC for binding to MAX to form a sequence-specific DNA-binding complex.[6] MXD3 is a transcriptional repressor that is specifically expressed during S phase of the
cell cycle.[7] The protein is implicated in both normal neural development and in the development of brain cancer. In
medulloblastoma cells, MXD3 binds
E-box sequences, leading to increased cell proliferation at moderate MXD3 levels but increased cell death and
apoptosis at higher expression levels.[8]
MAX dimerization protein 3 is a
protein that in humans is encoded by the MXD3gene located on Chromosome 5.[5][6]
MXD3 is a
basic helix-loop-helix protein belonging to a subfamily of
MAX-interacting proteins. This protein competes with
MYC for binding to MAX to form a sequence-specific DNA-binding complex.[6] MXD3 is a transcriptional repressor that is specifically expressed during S phase of the
cell cycle.[7] The protein is implicated in both normal neural development and in the development of brain cancer. In
medulloblastoma cells, MXD3 binds
E-box sequences, leading to increased cell proliferation at moderate MXD3 levels but increased cell death and
apoptosis at higher expression levels.[8]