From Wikipedia, the free encyclopedia
HDAC4
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
2H8N ,
2O94 ,
2VQJ ,
2VQM ,
2VQO ,
2VQQ ,
2VQV ,
2VQW ,
3UXG ,
3UZD ,
3V31 ,
4CBT ,
4CBY ,
5A2S
Identifiers
Aliases
HDAC4 , AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, histone deacetylase 4, NEDCHIDExternal IDs
OMIM :
605314 ;
MGI :
3036234 ;
HomoloGene :
55946 ;
GeneCards :
HDAC4 ;
OMA :
HDAC4 - orthologs
RNA expression pattern
Bgee
Human
Mouse (ortholog)
Top expressed in sural nerve glutes gastrocnemius muscle tibialis anterior muscle muscle of thigh muscle layer of sigmoid colon endothelial cell deltoid muscle Skeletal muscle tissue of biceps brachii blood
Top expressed in otic vesicle granulocyte gastrula Rostral migratory stream dentate gyrus of hippocampal formation granule cell muscle of thigh lip interventricular septum muscle tissue skeletal muscle tissue
More reference expression data
BioGPS
Wikidata
Histone deacetylase 4 , also known as HDAC4 , is a
protein that in humans is encoded by the HDAC4
gene .
[5]
[6]
Histones play a critical role in
transcriptional regulation ,
cell cycle progression, and developmental events. Histone
acetylation /deacetylation alters
chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the
histone deacetylase /acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly but through
transcription factors
MEF2C and
MEF2D . It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
[7] Furthermore, HDAC4 is required for TGFbeta1-induced myofibroblastic differentiation.
[8]
Studies have shown that HDAC4 regulates bone and muscle development.
Harvard University researchers also concluded that it promotes healthy vision: Reduced levels of the protein led to the death of the rod
photoreceptors and bipolar cells in the
retinas of mice.
[9]
[10]
HDAC4 has been shown to
interact with:
BCL6 ,
[11]
BTG2 ,
[12]
[13]
CBX5 ,
[14]
GATA1 ,
[15]
HDAC3 ,
[5]
[16]
[17]
[18]
MAPK1 ,
[19]
MAPK3 ,
[19]
MEF2C ,
[20]
[21]
Myocyte-specific enhancer factor 2A ,
[22]
[23]
Nuclear receptor co-repressor 1 ,
[16]
[24]
Nuclear receptor co-repressor 2 ,
[16]
[24]
Testicular receptor 2 ,
[25]
[26]
YWHAB ,
[17]
YWHAE ,
[17]
[27] and
Zinc finger and BTB domain-containing protein 16 .
[11]
[28]
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000068024 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000026313 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Grozinger CM, Hassig CA, Schreiber SL (April 1999).
"Three proteins define a class of human histone deacetylases related to yeast Hda1p" . Proceedings of the National Academy of Sciences of the United States of America . 96 (9): 4868–73.
Bibcode :
1999PNAS...96.4868G .
doi :
10.1073/pnas.96.9.4868 .
PMC
21783 .
PMID
10220385 .
^ Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E (April 1999).
"A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p" . The Journal of Biological Chemistry . 274 (17): 11713–20.
doi :
10.1074/jbc.274.17.11713 .
PMID
10206986 .
^
"Entrez Gene: HDAC4 histone deacetylase 4" .
^ Glenisson W, Castronovo V, Waltregny D (October 2007).
"Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation" . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1773 (10): 1572–82.
doi :
10.1016/j.bbamcr.2007.05.016 .
PMID
17610967 .
^ Protein for Sight ,
Scientific American , 300 , 3 (March 2009), p. 23
^ Chen B, Cepko CL (January 2009).
"HDAC4 regulates neuronal survival in normal and diseased retinas" . Science . 323 (5911): 256–9.
doi :
10.1126/science.1166226 .
PMC
3339762 .
PMID
19131628 .
^
a
b Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S (June 2002).
"Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor" . The Journal of Biological Chemistry . 277 (24): 22045–52.
doi :
10.1074/jbc.M201736200 .
PMID
11929873 .
^ Farioli-Vecchioli S, Tanori M, Micheli L, Mancuso M, Leonardi L, Saran A, Ciotti MT, Ferretti E, Gulino A, Pazzaglia S, Tirone F (July 2007).
"Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3" . FASEB Journal . 21 (9): 2215–25.
doi :
10.1096/fj.06-7548com .
PMID
17371797 .
S2CID
4974360 .
^ Micheli L, D'Andrea G, Leonardi L, Tirone F (July 2017).
"HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression" (PDF) . Journal of Cellular Physiology . 232 (7): 1696–1707.
doi :
10.1002/jcp.25467 .
PMID
27333946 .
S2CID
4070837 .
^ Zhang CL, McKinsey TA, Olson EN (October 2002).
"Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation" . Molecular and Cellular Biology . 22 (20): 7302–12.
doi :
10.1128/mcb.22.20.7302-7312.2002 .
PMC
139799 .
PMID
12242305 .
^ Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, Naoe T, Saito H (December 2003).
"Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation" . Oncogene . 22 (57): 9176–84.
doi :
10.1038/sj.onc.1206902 .
PMID
14668799 .
^
a
b
c Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Molecular Cell . 9 (1): 45–57.
doi :
10.1016/s1097-2765(01)00429-4 .
hdl :
11858/00-001M-0000-002C-9FF9-9 .
PMID
11804585 .
^
a
b
c Grozinger CM, Schreiber SL (July 2000).
"Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization" . Proceedings of the National Academy of Sciences of the United States of America . 97 (14): 7835–40.
Bibcode :
2000PNAS...97.7835G .
doi :
10.1073/pnas.140199597 .
PMC
16631 .
PMID
10869435 .
^ Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001).
"Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo" . The Journal of Biological Chemistry . 276 (38): 35826–35.
doi :
10.1074/jbc.M104935200 .
PMID
11466315 .
^
a
b Zhou X, Richon VM, Wang AH, Yang XJ, Rifkind RA, Marks PA (December 2000).
"Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras" . Proceedings of the National Academy of Sciences of the United States of America . 97 (26): 14329–33.
Bibcode :
2000PNAS...9714329Z .
doi :
10.1073/pnas.250494697 .
PMC
18918 .
PMID
11114188 .
^ Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ (November 1999).
"HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor" . Molecular and Cellular Biology . 19 (11): 7816–27.
doi :
10.1128/mcb.19.11.7816 .
PMC
84849 .
PMID
10523670 .
^ Wang AH, Yang XJ (September 2001).
"Histone deacetylase 4 possesses intrinsic nuclear import and export signals" . Molecular and Cellular Biology . 21 (17): 5992–6005.
doi :
10.1128/mcb.21.17.5992-6005.2001 .
PMC
87317 .
PMID
11486037 .
^ Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T (September 1999).
"HDAC4 deacetylase associates with and represses the MEF2 transcription factor" . The EMBO Journal . 18 (18): 5099–107.
doi :
10.1093/emboj/18.18.5099 .
PMC
1171580 .
PMID
10487761 .
^ Lemercier C, Verdel A, Galloo B, Curtet S, Brocard MP, Khochbin S (May 2000).
"mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity" (PDF) . The Journal of Biological Chemistry . 275 (20): 15594–9.
doi :
10.1074/jbc.M908437199 .
PMID
10748098 .
S2CID
39220205 .
^
a
b Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA (January 2000).
"Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway" . Genes & Development . 14 (1): 45–54.
doi :
10.1101/gad.14.1.45 .
PMC
316335 .
PMID
10640275 .
^ Franco PJ, Li G, Wei LN (August 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Molecular and Cellular Endocrinology . 206 (1–2): 1–12.
doi :
10.1016/s0303-7207(03)00254-5 .
PMID
12943985 .
S2CID
19487189 .
^ Franco PJ, Farooqui M, Seto E, Wei LN (August 2001).
"The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases" . Molecular Endocrinology . 15 (8): 1318–28.
doi :
10.1210/mend.15.8.0682 .
PMID
11463856 .
^ Miska EA, Langley E, Wolf D, Karlsson C, Pines J, Kouzarides T (August 2001).
"Differential localization of HDAC4 orchestrates muscle differentiation" . Nucleic Acids Research . 29 (16): 3439–47.
doi :
10.1093/nar/29.16.3439 .
PMC
55849 .
PMID
11504882 .
^ Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A (November 2004).
"HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF" . Oncogene . 23 (54): 8777–84.
doi :
10.1038/sj.onc.1208128 .
PMID
15467736 .
Pazin MJ, Kadonaga JT (May 1997).
"What's up and down with histone deacetylation and transcription?" . Cell . 89 (3): 325–8.
doi :
10.1016/S0092-8674(00)80211-1 .
PMID
9150131 .
S2CID
11488594 .
Verdin E, Dequiedt F, Kasler HG (May 2003). "Class II histone deacetylases: versatile regulators". Trends in Genetics . 19 (5): 286–93.
doi :
10.1016/S0168-9525(03)00073-8 .
hdl :
2268/80861 .
PMID
12711221 .
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry . 236 (1): 107–13.
doi :
10.1006/abio.1996.0138 .
PMID
8619474 .
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997).
"Large-scale concatenation cDNA sequencing" . Genome Research . 7 (4): 353–8.
doi :
10.1101/gr.7.4.353 .
PMC
139146 .
PMID
9110174 .
Wolffe AP (May 1997).
"Transcriptional control. Sinful repression" . Nature . 387 (6628): 16–7.
doi :
10.1038/387016a0 .
PMID
9139815 .
S2CID
29803420 .
Ohara O, Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Nomura N (February 1997).
"Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins" . DNA Research . 4 (1): 53–9.
doi :
10.1093/dnares/4.1.53 .
PMID
9179496 .
Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E (April 1999).
"A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p" . The Journal of Biological Chemistry . 274 (17): 11713–20.
doi :
10.1074/jbc.274.17.11713 .
PMID
10206986 .
Grozinger CM, Hassig CA, Schreiber SL (April 1999).
"Three proteins define a class of human histone deacetylases related to yeast Hda1p" . Proceedings of the National Academy of Sciences of the United States of America . 96 (9): 4868–73.
Bibcode :
1999PNAS...96.4868G .
doi :
10.1073/pnas.96.9.4868 .
PMC
21783 .
PMID
10220385 .
Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T (September 1999).
"HDAC4 deacetylase associates with and represses the MEF2 transcription factor" . The EMBO Journal . 18 (18): 5099–107.
doi :
10.1093/emboj/18.18.5099 .
PMC
1171580 .
PMID
10487761 .
Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ (November 1999).
"HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor" . Molecular and Cellular Biology . 19 (11): 7816–27.
doi :
10.1128/mcb.19.11.7816 .
PMC
84849 .
PMID
10523670 .
Youn HD, Grozinger CM, Liu JO (July 2000).
"Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4" . The Journal of Biological Chemistry . 275 (29): 22563–7.
doi :
10.1074/jbc.C000304200 .
PMID
10825153 .
Grozinger CM, Schreiber SL (July 2000).
"Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization" . Proceedings of the National Academy of Sciences of the United States of America . 97 (14): 7835–40.
Bibcode :
2000PNAS...97.7835G .
doi :
10.1073/pnas.140199597 .
PMC
16631 .
PMID
10869435 .
Huynh KD, Fischle W, Verdin E, Bardwell VJ (July 2000).
"BCoR, a novel corepressor involved in BCL-6 repression" . Genes & Development . 14 (14): 1810–23.
doi :
10.1101/gad.14.14.1810 .
PMC
316791 .
PMID
10898795 .
Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (August 2000).
"Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3" . The EMBO Journal . 19 (16): 4342–50.
doi :
10.1093/emboj/19.16.4342 .
PMC
302030 .
PMID
10944117 .
Wang AH, Kruhlak MJ, Wu J, Bertos NR, Vezmar M, Posner BI, Bazett-Jones DP, Yang XJ (September 2000).
"Regulation of histone deacetylase 4 by binding of 14-3-3 proteins" . Molecular and Cellular Biology . 20 (18): 6904–12.
doi :
10.1128/MCB.20.18.6904-6912.2000 .
PMC
88766 .
PMID
10958686 .
Zhang CL, McKinsey TA, Lu JR, Olson EN (January 2001).
"Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor" . The Journal of Biological Chemistry . 276 (1): 35–9.
doi :
10.1074/jbc.M007364200 .
PMID
11022042 .
McKinsey TA, Zhang CL, Lu J, Olson EN (November 2000).
"Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation" . Nature . 408 (6808): 106–11.
Bibcode :
2000Natur.408..106M .
doi :
10.1038/35040593 .
PMC
4459600 .
PMID
11081517 .
Zhou X, Richon VM, Wang AH, Yang XJ, Rifkind RA, Marks PA (December 2000).
"Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras" . Proceedings of the National Academy of Sciences of the United States of America . 97 (26): 14329–33.
Bibcode :
2000PNAS...9714329Z .
doi :
10.1073/pnas.250494697 .
PMC
18918 .
PMID
11114188 .
McKinsey TA, Zhang CL, Olson EN (December 2000).
"Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5" . Proceedings of the National Academy of Sciences of the United States of America . 97 (26): 14400–5.
Bibcode :
2000PNAS...9714400M .
doi :
10.1073/pnas.260501497 .
PMC
18930 .
PMID
11114197 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
Activity Regulation Classification Kinetics Types