From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
RBPJ
Identifiers
Aliases
RBPJ , AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl, recombination signal binding protein for immunoglobulin kappa J region, RBP-J kappa, RBP-JK, CBF-1External IDs
OMIM :
147183 ;
MGI :
96522 ;
HomoloGene :
7511 ;
GeneCards :
RBPJ ;
OMA :
RBPJ - orthologs
Wikidata
Recombination signal binding protein for immunoglobulin kappa J region is a
protein that in humans is encoded by the RBPJ
gene .
[5]
[6]
[7]
RBPJ
[8] also known as CBF1, is the human homolog for the
Drosophila gene
Suppressor of Hairless . Its
promoter region is classically used to demonstrate
Notch1 signaling.
[9]
RBPJ has been shown to
interact with:
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000168214 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000039191 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Amakawa R, Jing W, Ozawa K, et al. (August 1993). "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue". Genomics . 17 (2): 306–315.
doi :
10.1006/geno.1993.1326 .
PMID
8406481 .
^ Tang X, Saito-Ohara F, Song J, et al. (June 1997).
"Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization" . The Japanese Journal of Human Genetics . 42 (2): 337–341.
doi :
10.1007/BF02766956 .
PMID
9290259 .
^
"NCBI Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region" .
^
"HGNC: RBPJ Symbol Report" .
^ Hsieh JJ, Henkel T, Salmon P, et al. (March 1996).
"Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2" . Molecular and Cellular Biology . 16 (3): 952–959.
doi :
10.1128/mcb.16.3.952 .
PMC
231077 .
PMID
8622698 .
^ Nam Y, Weng AP, Aster JC, et al. (June 2003).
"Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex" . The Journal of Biological Chemistry . 278 (23): 21232–21239.
doi :
10.1074/jbc.M301567200 .
PMID
12644465 .
^ Aster JC, Robertson ES, Hasserjian RP, et al. (April 1997).
"Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription" . The Journal of Biological Chemistry . 272 (17): 11336–11343.
doi :
10.1074/jbc.272.17.11336 .
PMID
9111040 .
^ Beatus P, Lundkvist J, Oberg C, et al. (June 2001).
"The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity" . Mechanisms of Development . 104 (1–2): 3–20.
doi :
10.1016/s0925-4773(01)00373-2 .
PMID
11404076 .
S2CID
9526831 .
^ Zhou S, Hayward SD (September 2001).
"Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex" . Molecular and Cellular Biology . 21 (18): 6222–6232.
doi :
10.1128/mcb.21.18.6222-6232.2001 .
PMC
87339 .
PMID
11509665 .
^ Kurooka H, Honjo T (June 2000).
"Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5" . The Journal of Biological Chemistry . 275 (22): 17211–17220.
doi :
10.1074/jbc.M000909200 .
PMID
10747963 .
^
a
b Zhou S, Fujimuro M, Hsieh JJ, et al. (February 2000).
"A role for SKIP in EBNA2 activation of CBF1-repressed promoters" . Journal of Virology . 74 (4): 1939–1947.
doi :
10.1128/jvi.74.4.1939-1947.2000 .
PMC
111672 .
PMID
10644367 .
^ Hsieh JJ, Zhou S, Chen L, et al. (January 1999).
"CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex" . Proceedings of the National Academy of Sciences of the United States of America . 96 (1): 23–28.
Bibcode :
1999PNAS...96...23H .
doi :
10.1073/pnas.96.1.23 .
PMC
15086 .
PMID
9874765 .
^ Zhou S, Fujimuro M, Hsieh JJ, et al. (April 2000).
"SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function" . Molecular and Cellular Biology . 20 (7): 2400–2410.
doi :
10.1128/mcb.20.7.2400-2410.2000 .
PMC
85419 .
PMID
10713164 .
^ Overman J, Fontaine F, Wylie-Sears J, et al. (July 2019). van Lohuizen M, Koh GY, Ostergaard P (eds.).
"R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma" . eLife . 8 : e43026.
doi :
10.7554/eLife.43026 .
PMC
6667216 .
PMID
31358114 .
^ Díaz-Trelles R, Scimia MC, Bushway P, et al. (June 2016).
"Notch-independent RBPJ controls angiogenesis in the adult heart" . Nature Communications . 7 (1): 12088.
Bibcode :
2016NatCo...712088D .
doi :
10.1038/ncomms12088 .
PMC
4931341 .
PMID
27357444 .
Oka C, Kawaichi M (1995). "V(D)J recombination of immunoglobulin genes". Advances in Biophysics . 31 : 163–180.
doi :
10.1016/0065-227X(95)99390-B .
PMID
7625272 .
Matsunami N, Hamaguchi Y, Yamamoto Y, et al. (1990). "A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif". Nature . 342 (6252): 934–937.
doi :
10.1038/342934a0 .
PMID
2556644 .
S2CID
4370462 .
Tong X, Drapkin R, Yalamanchili R, et al. (September 1995).
"The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE" . Molecular and Cellular Biology . 15 (9): 4735–4744.
doi :
10.1128/mcb.15.9.4735 .
PMC
230717 .
PMID
7651391 .
Zhao B, Marshall DR, Sample CE (July 1996).
"A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of Jkappa" . Journal of Virology . 70 (7): 4228–4236.
doi :
10.1128/JVI.70.7.4228-4236.1996 .
PMC
190353 .
PMID
8676443 .
Tamura K, Taniguchi Y, Minoguchi S, et al. (December 1995). "Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)". Current Biology . 5 (12): 1416–1423.
Bibcode :
1995CBio....5.1416T .
doi :
10.1016/S0960-9822(95)00279-X .
hdl :
2433/202204 .
PMID
8749394 .
S2CID
18442572 .
Gress TM, Müller-Pillasch F, Geng M, et al. (October 1996). "A pancreatic cancer-specific expression profile". Oncogene . 13 (8): 1819–1830.
PMID
8895530 .
Hsieh JJ, Nofziger DE, Weinmaster G, et al. (March 1997).
"Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation" . Journal of Virology . 71 (3): 1938–1945.
doi :
10.1128/JVI.71.3.1938-1945.1997 .
PMC
191274 .
PMID
9032325 .
Aster JC, Robertson ES, Hasserjian RP, et al. (April 1997).
"Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription" . The Journal of Biological Chemistry . 272 (17): 11336–11343.
doi :
10.1074/jbc.272.17.11336 .
PMID
9111040 .
Kao HY, Ordentlich P, Koyano-Nakagawa N, et al. (August 1998).
"A histone deacetylase corepressor complex regulates the Notch signal transduction pathway" . Genes & Development . 12 (15): 2269–2277.
doi :
10.1101/gad.12.15.2269 .
PMC
317043 .
PMID
9694793 .
Hsieh JJ, Zhou S, Chen L, et al. (January 1999).
"CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex" . Proceedings of the National Academy of Sciences of the United States of America . 96 (1): 23–28.
Bibcode :
1999PNAS...96...23H .
doi :
10.1073/pnas.96.1.23 .
PMC
15086 .
PMID
9874765 .
Scanlan MJ, Gordan JD, Williamson B, et al. (November 1999).
"Antigens recognized by autologous antibody in patients with renal-cell carcinoma" . International Journal of Cancer . 83 (4): 456–464.
doi :
10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 .
PMID
10508479 .
Callahan J, Aster J, Sklar J, et al. (January 2000).
"Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells" . Leukemia . 14 (1): 84–92.
doi :
10.1038/sj.leu.2401630 .
PMID
10637481 .
Smith PR, de Jesus O, Turner D, et al. (April 2000).
"Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus" . Journal of Virology . 74 (7): 3082–3092.
doi :
10.1128/JVI.74.7.3082-3092.2000 .
PMC
111807 .
PMID
10708423 .
Zhou S, Fujimuro M, Hsieh JJ, et al. (April 2000).
"SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function" . Molecular and Cellular Biology . 20 (7): 2400–2410.
doi :
10.1128/MCB.20.7.2400-2410.2000 .
PMC
85419 .
PMID
10713164 .
Kurooka H, Honjo T (June 2000).
"Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5" . The Journal of Biological Chemistry . 275 (22): 17211–17220.
doi :
10.1074/jbc.M000909200 .
PMID
10747963 .
Beatus P, Lundkvist J, Oberg C, et al. (June 2001).
"The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity" . Mechanisms of Development . 104 (1–2): 3–20.
doi :
10.1016/S0925-4773(01)00373-2 .
PMID
11404076 .
S2CID
9526831 .
Zhou S, Hayward SD (September 2001).
"Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex" . Molecular and Cellular Biology . 21 (18): 6222–6232.
doi :
10.1128/MCB.21.18.6222-6232.2001 .
PMC
87339 .
PMID
11509665 .
(1) Basic domains
(1.1) Basic
leucine zipper (
bZIP )(1.2) Basic helix-loop-helix (
bHLH )
Group A Group B Group C bHLH-
PAS Group D Group E Group F bHLH-COE
(1.3)
bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2)
Zinc finger DNA-binding domains
(2.1)
Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .