Neurogenic locus notch homolog protein 1(Notch 1) is a protein encoded in humans by the NOTCH1gene.[5] Notch 1 is a single-pass transmembrane
receptor.
Function
This gene encodes a member of the
Notch family. Members of this
type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple
epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an
evolutionarily conserved intercellular
signaling pathway that regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in humans, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the
trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.[6]
There is evidence that activated Notch 1 and
Notch 3 promote differentiation of progenitor cells into
astroglia.[8] Notch 1, when activated before birth, induces
radial glia differentiation,[9] but postnatally induces the differentiation into
astrocytes.[10] One study shows that Notch-1 cascade is activated by
Reelin in an unidentified way.[11] Reelin and Notch1 cooperate in the development of the
dentate gyrus, according to another.[12]
^Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (June 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mech. Dev. 104 (1–2): 3–20.
doi:
10.1016/s0925-4773(01)00373-2.
PMID11404076.
S2CID9526831.
Neurogenic locus notch homolog protein 1(Notch 1) is a protein encoded in humans by the NOTCH1gene.[5] Notch 1 is a single-pass transmembrane
receptor.
Function
This gene encodes a member of the
Notch family. Members of this
type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple
epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an
evolutionarily conserved intercellular
signaling pathway that regulates interactions between physically adjacent cells. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in humans, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the
trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.[6]
There is evidence that activated Notch 1 and
Notch 3 promote differentiation of progenitor cells into
astroglia.[8] Notch 1, when activated before birth, induces
radial glia differentiation,[9] but postnatally induces the differentiation into
astrocytes.[10] One study shows that Notch-1 cascade is activated by
Reelin in an unidentified way.[11] Reelin and Notch1 cooperate in the development of the
dentate gyrus, according to another.[12]
^Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (June 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mech. Dev. 104 (1–2): 3–20.
doi:
10.1016/s0925-4773(01)00373-2.
PMID11404076.
S2CID9526831.