IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of
virus-inducible cellular genes, including the
type I interferon genes. In particular, IRF7 regulates many
interferon-alpha genes.[5] Constitutive expression of IRF7 is largely restricted to
lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.[6]
The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response.[7] Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models.
The IRF7 gene and product were shown to be defective in a patient with severe susceptibility to H1N1
influenza, while susceptibility to other viral diseases such as CMV, RSV, and
parainfluenza was unaffected.[8]
^Bidwell (2012). "Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape". Nature Medicine. 18 (8): 1224–1231.
doi:
10.1038/nm.2830.
PMID22820642.
S2CID6727932.
Paris MJ, Williams BR (October 2000). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics. 69 (2): 196–202.
doi:
10.1006/geno.2000.6339.
PMID11031102.
Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (February 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine. 9 (2): 191–7.
doi:
10.1038/nm822.
PMID12539042.
S2CID26145639.
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of
virus-inducible cellular genes, including the
type I interferon genes. In particular, IRF7 regulates many
interferon-alpha genes.[5] Constitutive expression of IRF7 is largely restricted to
lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.[6]
The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response.[7] Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models.
The IRF7 gene and product were shown to be defective in a patient with severe susceptibility to H1N1
influenza, while susceptibility to other viral diseases such as CMV, RSV, and
parainfluenza was unaffected.[8]
^Bidwell (2012). "Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape". Nature Medicine. 18 (8): 1224–1231.
doi:
10.1038/nm.2830.
PMID22820642.
S2CID6727932.
Paris MJ, Williams BR (October 2000). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics. 69 (2): 196–202.
doi:
10.1006/geno.2000.6339.
PMID11031102.
Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (February 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine. 9 (2): 191–7.
doi:
10.1038/nm822.
PMID12539042.
S2CID26145639.