Suppressor of cytokine signaling 1 is a
protein that in humans is encoded by the SOCS1gene.[5][6]SOCS1orthologs[7] have been identified in several
mammals for which complete genome data are available.
Function
This gene encodes a member of the
STAT-induced STAT inhibitor (SSI), also known as
suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of
cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including
IL2,
IL3,
erythropoietin (EPO),
GM-CSF, and
interferon-gamma (IFN-γ). The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a
negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-γ action, which is required for normal postnatal growth and survival.[8]
Several recent viral studies have shown that viral genes, such as Tax gene product (Tax), encoded by HTLV-1, could hijack SOCS1 to inhibit host antiviral pathways, as a strategy to evade host immunity.[9]
Interactions
The suppressor of cytokine signaling 1 has been shown to
interact with:
^Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (August 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochemical and Biophysical Research Communications. 237 (1): 79–83.
doi:
10.1006/bbrc.1997.7080.
PMID9266833.
^Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (October 1997). "Cloning and characterization of novel CIS family genes". Biochemical and Biophysical Research Communications. 239 (2): 439–46.
doi:
10.1006/bbrc.1997.7484.
PMID9344848.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences. 27 (5): 235–41.
doi:
10.1016/S0968-0004(02)02085-6.
PMID12076535.
Yandava CN, Pillari A, Drazen JM (October 1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively". Genomics. 61 (1): 108–11.
doi:
10.1006/geno.1999.5937.
PMID10512686.
Suppressor of cytokine signaling 1 is a
protein that in humans is encoded by the SOCS1gene.[5][6]SOCS1orthologs[7] have been identified in several
mammals for which complete genome data are available.
Function
This gene encodes a member of the
STAT-induced STAT inhibitor (SSI), also known as
suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of
cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including
IL2,
IL3,
erythropoietin (EPO),
GM-CSF, and
interferon-gamma (IFN-γ). The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a
negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-γ action, which is required for normal postnatal growth and survival.[8]
Several recent viral studies have shown that viral genes, such as Tax gene product (Tax), encoded by HTLV-1, could hijack SOCS1 to inhibit host antiviral pathways, as a strategy to evade host immunity.[9]
Interactions
The suppressor of cytokine signaling 1 has been shown to
interact with:
^Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (August 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochemical and Biophysical Research Communications. 237 (1): 79–83.
doi:
10.1006/bbrc.1997.7080.
PMID9266833.
^Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (October 1997). "Cloning and characterization of novel CIS family genes". Biochemical and Biophysical Research Communications. 239 (2): 439–46.
doi:
10.1006/bbrc.1997.7484.
PMID9344848.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences. 27 (5): 235–41.
doi:
10.1016/S0968-0004(02)02085-6.
PMID12076535.
Yandava CN, Pillari A, Drazen JM (October 1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively". Genomics. 61 (1): 108–11.
doi:
10.1006/geno.1999.5937.
PMID10512686.