Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a
protein that in humans is encoded by the YBX1gene.[5]
Clinical significance
YBX1 is a potential drug target in cancer therapy.[6] YB-1 helps the replication of
adenovirus type 5, a commonly used vector in
gene therapy.[6] Thus, YB-1 can cause an
"oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.
Interactions
Y box binding protein 1 has been shown to
interact with:
^
abKojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G (2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". J. Mol. Biol. 339 (2): 313–25.
doi:
10.1016/j.jmb.2004.03.071.
PMID15136035.
^Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. 59 (2): 342–6.
PMID9927044.
^Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ (2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1". J. Mol. Biol. 384 (4): 908–16.
doi:
10.1016/j.jmb.2008.09.060.
PMID18851979.
Sakura H, Maekawa T, Imamoto F, et al. (1989). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology". Gene. 73 (2): 499–507.
doi:
10.1016/0378-1119(88)90514-8.
PMID2977358.
Kudo S, Mattei MG, Fukuda M (1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain". Eur. J. Biochem. 231 (1): 72–82.
doi:
10.1111/j.1432-1033.1995.tb20672.x.
PMID7628487.
Toh S, Nakamura T, Ohga T, et al. (1998). "Genomic organization of the human Y-box protein (YB-1) gene". Gene. 206 (1): 93–7.
doi:
10.1016/S0378-1119(97)00570-2.
PMID9461420.
Ise T, Nagatani G, Imamura T, et al. (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. 59 (2): 342–6.
PMID9927044.
1h95: SOLUTION STRUCTURE OF THE SINGLE-STRANDED DNA-BINDING COLD SHOCK DOMAIN (CSD) OF HUMAN Y-BOX PROTEIN 1 (YB1) DETERMINED BY NMR (10 LOWEST ENERGY STRUCTURES)
Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a
protein that in humans is encoded by the YBX1gene.[5]
Clinical significance
YBX1 is a potential drug target in cancer therapy.[6] YB-1 helps the replication of
adenovirus type 5, a commonly used vector in
gene therapy.[6] Thus, YB-1 can cause an
"oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.
Interactions
Y box binding protein 1 has been shown to
interact with:
^
abKojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G (2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". J. Mol. Biol. 339 (2): 313–25.
doi:
10.1016/j.jmb.2004.03.071.
PMID15136035.
^Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. 59 (2): 342–6.
PMID9927044.
^Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ (2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1". J. Mol. Biol. 384 (4): 908–16.
doi:
10.1016/j.jmb.2008.09.060.
PMID18851979.
Sakura H, Maekawa T, Imamoto F, et al. (1989). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology". Gene. 73 (2): 499–507.
doi:
10.1016/0378-1119(88)90514-8.
PMID2977358.
Kudo S, Mattei MG, Fukuda M (1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain". Eur. J. Biochem. 231 (1): 72–82.
doi:
10.1111/j.1432-1033.1995.tb20672.x.
PMID7628487.
Toh S, Nakamura T, Ohga T, et al. (1998). "Genomic organization of the human Y-box protein (YB-1) gene". Gene. 206 (1): 93–7.
doi:
10.1016/S0378-1119(97)00570-2.
PMID9461420.
Ise T, Nagatani G, Imamura T, et al. (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. 59 (2): 342–6.
PMID9927044.
1h95: SOLUTION STRUCTURE OF THE SINGLE-STRANDED DNA-BINDING COLD SHOCK DOMAIN (CSD) OF HUMAN Y-BOX PROTEIN 1 (YB1) DETERMINED BY NMR (10 LOWEST ENERGY STRUCTURES)