NEW ETS-RELATED FACTOR

ELF2
Identifiers
Aliases	ELF2, EU32, NERF, NERF-1A, NERF-1B, NERF-1a,b, NERF-2, E74 like ETS transcription factor 2
External IDs	MGI: 1916507; HomoloGene: 5006; GeneCards: ELF2; OMA: ELF2 - orthologs
Gene location ( Human)
Chr.	Chromosome 4 (human)
End	139,177,218 bp
Gene location ( Mouse)
Chr.	Chromosome 3 (mouse)
End	51,248,084 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; epithelium of colon; ; ganglionic eminence; ; ventricular zone; ; muscle of thigh; ; Descending thoracic aorta; ; right lung; ; skin of thigh; ; skin of hip; ; ascending aorta;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; ventricular zone; ; zygote; ; ganglionic eminence; ; dermis; ; Rostral migratory stream; ; tail of embryo; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; cytosol; nuclear body; nucleoplasm;
Biological process	regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; cell differentiation; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of B cell receptor signaling pathway;
	Sources: Amigo / QuickGO
Orthologs
	1998
	69257
	ENSG00000109381
	ENSMUSG00000037174
	Q15723
	Q9JHC9
NM_001276457; NM_001276458; NM_001276459; NM_006874; NM_201999;
	NM_001331036
	NM_001291059; NM_001291062; NM_001291063; NM_023502; NM_001356358
NP_001263386; NP_001263387; NP_001263388; NP_001317965; NP_006865;
	NP_973728; NP_001358253; NP_001358265; NP_001358266; NP_001358267; NP_001358268
	NP_001277988; NP_001277991; NP_001277992; NP_075991; NP_001343287
	Wikidata
View/Edit Human	View/Edit Mouse

E74-like factor 2 (ELF2), formerly known as new Ets-related factor (NERF), is an ETS family transcription factor.^[5] In humans this protein is encoded by the ELF2 gene.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109381 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037174 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA (September 1996). "Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1". Mol. Cell. Biol. 16 (9): 5091–106. doi: 10.1128/MCB.16.9.5091. PMC 231510. PMID 8756667.
^ "Entrez Gene: ELF2 E74-like factor 2 (ets domain transcription factor)".

Wilkinson DA, Neale GA, Mao S, et al. (1997). "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia". Leukemia. 11 (1): 86–96. doi: 10.1038/sj.leu.2400516. PMID 9001422.
Mao S, Frank RC, Zhang J, et al. (1999). "Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias". Mol. Cell. Biol. 19 (5): 3635–44. doi: 10.1128/mcb.19.5.3635. PMC 84165. PMID 10207087.
Christensen RA, Fujikawa K, Madore R, et al. (2002). "NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia". J. Cell. Biochem. 85 (3): 505–15. doi: 10.1002/jcb.10148. PMID 11967990. S2CID 36902890.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cho JY, Akbarali Y, Zerbini LF, et al. (2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". J. Biol. Chem. 279 (19): 19512–22. doi: 10.1074/jbc.M309074200. PMID 14970218.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode: 2004PNAS..10112130B. doi: 10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang B, Tomita Y, Qiu Y, et al. (2007). "E74-like factor 2 regulates valosin-containing protein expression". Biochem. Biophys. Res. Commun. 356 (3): 536–41. doi: 10.1016/j.bbrc.2007.02.160. PMID 17368566.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109381 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037174 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Oett-5] Oettgen P, Akbarali Y, Boltax J, Best J, Kunsch C, Libermann TA (September 1996). "Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1". Mol. Cell. Biol. 16 (9): 5091–106. doi: 10.1128/MCB.16.9.5091. PMC 231510. PMID 8756667.

[entrez-6] "Entrez Gene: ELF2 E74-like factor 2 (ets domain transcription factor)".

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