(Redirected from
JUNB (gene))
Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene. [5] [6] Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.
Interactions
JUNB has been shown to interact with
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000171223 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052837 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun". Cell. 59 (6): 987–997. doi: 10.1016/0092-8674(89)90755-1. PMID 2513129.
- ^ "Entrez Gene: JUNB jun B proto-oncogene".
- ^ Hu YF, Li R (Jun 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. 16 (12): 1509–17. doi: 10.1101/gad.995502. PMC 186344. PMID 12080089.
- ^ Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (Apr 1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. Bibcode: 1999PNAS...96.4844L. doi: 10.1073/pnas.96.9.4844. PMC 21779. PMID 10220381.
Further reading
- Hsu JC, Bravo R, Taub R (1992). "Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration". Mol. Cell. Biol. 12 (10): 4654–65. doi: 10.1128/MCB.12.10.4654. PMC 360392. PMID 1406655.
- Zafarullah M, Martel-Pelletier J, Cloutier JM, Gedamu L, Pelletier JP (1992). "Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte". FEBS Lett. 306 (2–3): 169–172. doi: 10.1016/0014-5793(92)80992-P. PMID 1633872. S2CID 43460076.
- Mollinedo F, Vaquerizo MJ, Naranjo JR (1991). "Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes". Biochem. J. 273(Pt 2) (2): 477–9. doi: 10.1042/bj2730477. PMC 1149869. PMID 1899335.
- Nomura N, Ide M, Sasamoto S, Matsui M, Date T, Ishizaki R (1990). "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D". Nucleic Acids Res. 18 (10): 3047–3048. doi: 10.1093/nar/18.10.3047. PMC 330838. PMID 2112242.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi: 10.1016/0378-1119(94)90802-8. PMID 8125298.
- Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–145. doi: 10.1006/geno.1993.1021. PMID 8432525.
- Phinney DG, Tseng SW, Ryder K (1996). "Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci". Genomics. 28 (2): 228–234. doi: 10.1006/geno.1995.1135. PMID 8530030.
- Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene. 11 (11): 2255–65. PMID 8570175.
- Neyns B, Vermeij J, Bourgain C, Vandamme B, Amfo K, Lissens W, DeSutter P, Hooghe-Peters E, DeGrève J (1996). "Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium". Oncogene. 12 (6): 1247–57. PMID 8649827.
- Mendelson KG, Contois LR, Tevosian SG, Davis RJ, Paulson KE (1996). "Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12908–12913. Bibcode: 1996PNAS...9312908M. doi: 10.1073/pnas.93.23.12908. PMC 24019. PMID 8917518.
- Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M (1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions". Mol. Cell. Biol. 17 (6): 3094–102. doi: 10.1128/mcb.17.6.3094. PMC 232162. PMID 9154808.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi: 10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z (1998). "c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors". J. Biol. Chem. 272 (51): 32163–32168. doi: 10.1074/jbc.272.51.32163. PMID 9405416.
- Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes". Oncogene. 17 (24): 3145–3156. doi: 10.1038/sj.onc.1202237. PMID 9872330.
- Li B, Tournier C, Davis RJ, Flavell RA (1999). "Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation". EMBO J. 18 (2): 420–432. doi: 10.1093/emboj/18.2.420. PMC 1171136. PMID 9889198.
- Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–4849. Bibcode: 1999PNAS...96.4844L. doi: 10.1073/pnas.96.9.4844. PMC 21779. PMID 10220381.
- Chen P, Flory E, Avots A, Jordan BW, Kirchhoff F, Ludwig S, Rapp UR (2000). "Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors". J. Biol. Chem. 275 (27): 20382–20390. doi: 10.1074/jbc.M001149200. PMID 10764760.
- Echlin DR, Tae HJ, Mitin N, Taparowsky EJ (2000). "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos". Oncogene. 19 (14): 1752–1763. doi: 10.1038/sj.onc.1203491. PMID 10777209.
- Verrecchia F, Pessah M, Atfi A, Mauviel A (2000). "Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation". J. Biol. Chem. 275 (39): 30226–30231. doi: 10.1074/jbc.M005310200. PMID 10903323.
- Singh K, Camera E, Krug L, Basu A, Pandey RK, Munir S, Wlaschek M, Kochanek S, Schorpp-Kistner M, Picardo M, Angel P, Niemann C, Maity P, Scharffetter-Kochanek K (2018). "JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin". Nature. 9 (1): 3425. Bibcode: 2018NatCo...9.3425S. doi: 10.1038/s41467-018-05726-z. PMC 6109099. PMID 30143626.
External links
- JUNB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it. |
(Redirected from
JUNB (gene))
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| Aliases | JUNB, AP-1, JunB proto-oncogene, AP-1 transcription factor subunit | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 165161; MGI: 96647; HomoloGene: 7390; GeneCards: JUNB; OMA: JUNB - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene. [5] [6] Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.
Interactions
JUNB has been shown to interact with
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000171223 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052837 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Schütte J, Viallet J, Nau M, Segal S, Fedorko J, Minna J (Feb 1990). "jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun". Cell. 59 (6): 987–997. doi: 10.1016/0092-8674(89)90755-1. PMID 2513129.
- ^ "Entrez Gene: JUNB jun B proto-oncogene".
- ^ Hu YF, Li R (Jun 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction". Genes Dev. 16 (12): 1509–17. doi: 10.1101/gad.995502. PMC 186344. PMID 12080089.
- ^ Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (Apr 1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. Bibcode: 1999PNAS...96.4844L. doi: 10.1073/pnas.96.9.4844. PMC 21779. PMID 10220381.
Further reading
- Hsu JC, Bravo R, Taub R (1992). "Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration". Mol. Cell. Biol. 12 (10): 4654–65. doi: 10.1128/MCB.12.10.4654. PMC 360392. PMID 1406655.
- Zafarullah M, Martel-Pelletier J, Cloutier JM, Gedamu L, Pelletier JP (1992). "Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte". FEBS Lett. 306 (2–3): 169–172. doi: 10.1016/0014-5793(92)80992-P. PMID 1633872. S2CID 43460076.
- Mollinedo F, Vaquerizo MJ, Naranjo JR (1991). "Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes". Biochem. J. 273(Pt 2) (2): 477–9. doi: 10.1042/bj2730477. PMC 1149869. PMID 1899335.
- Nomura N, Ide M, Sasamoto S, Matsui M, Date T, Ishizaki R (1990). "Isolation of human cDNA clones of jun-related genes, jun-B and jun-D". Nucleic Acids Res. 18 (10): 3047–3048. doi: 10.1093/nar/18.10.3047. PMC 330838. PMID 2112242.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi: 10.1016/0378-1119(94)90802-8. PMID 8125298.
- Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–145. doi: 10.1006/geno.1993.1021. PMID 8432525.
- Phinney DG, Tseng SW, Ryder K (1996). "Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci". Genomics. 28 (2): 228–234. doi: 10.1006/geno.1995.1135. PMID 8530030.
- Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene. 11 (11): 2255–65. PMID 8570175.
- Neyns B, Vermeij J, Bourgain C, Vandamme B, Amfo K, Lissens W, DeSutter P, Hooghe-Peters E, DeGrève J (1996). "Expression of the jun family of genes in human ovarian cancer and normal ovarian surface epithelium". Oncogene. 12 (6): 1247–57. PMID 8649827.
- Mendelson KG, Contois LR, Tevosian SG, Davis RJ, Paulson KE (1996). "Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12908–12913. Bibcode: 1996PNAS...9312908M. doi: 10.1073/pnas.93.23.12908. PMC 24019. PMID 8917518.
- Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M (1997). "Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions". Mol. Cell. Biol. 17 (6): 3094–102. doi: 10.1128/mcb.17.6.3094. PMC 232162. PMID 9154808.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi: 10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Fuchs SY, Xie B, Adler V, Fried VA, Davis RJ, Ronai Z (1998). "c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors". J. Biol. Chem. 272 (51): 32163–32168. doi: 10.1074/jbc.272.51.32163. PMID 9405416.
- Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes". Oncogene. 17 (24): 3145–3156. doi: 10.1038/sj.onc.1202237. PMID 9872330.
- Li B, Tournier C, Davis RJ, Flavell RA (1999). "Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation". EMBO J. 18 (2): 420–432. doi: 10.1093/emboj/18.2.420. PMC 1171136. PMID 9889198.
- Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF (1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–4849. Bibcode: 1999PNAS...96.4844L. doi: 10.1073/pnas.96.9.4844. PMC 21779. PMID 10220381.
- Chen P, Flory E, Avots A, Jordan BW, Kirchhoff F, Ludwig S, Rapp UR (2000). "Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway. The most frequent naturally occurring length polymorphism sequence introduces a novel binding site for AP-1 factors". J. Biol. Chem. 275 (27): 20382–20390. doi: 10.1074/jbc.M001149200. PMID 10764760.
- Echlin DR, Tae HJ, Mitin N, Taparowsky EJ (2000). "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos". Oncogene. 19 (14): 1752–1763. doi: 10.1038/sj.onc.1203491. PMID 10777209.
- Verrecchia F, Pessah M, Atfi A, Mauviel A (2000). "Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation". J. Biol. Chem. 275 (39): 30226–30231. doi: 10.1074/jbc.M005310200. PMID 10903323.
- Singh K, Camera E, Krug L, Basu A, Pandey RK, Munir S, Wlaschek M, Kochanek S, Schorpp-Kistner M, Picardo M, Angel P, Niemann C, Maity P, Scharffetter-Kochanek K (2018). "JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin". Nature. 9 (1): 3425. Bibcode: 2018NatCo...9.3425S. doi: 10.1038/s41467-018-05726-z. PMC 6109099. PMID 30143626.
External links
- JUNB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
| This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it. |