ERF (GENE)

ERF
Identifiers
Aliases	ERF, CRS4, PE-2, PE2, ETS2 repressor factor, CHYTS
External IDs	OMIM: 611888; MGI: 109637; HomoloGene: 68516; GeneCards: ERF; OMA: ERF - orthologs
Gene location ( Human)
Chr.	Chromosome 19 (human)
End	42,255,128 bp
Gene location ( Mouse)
Chr.	Chromosome 7 (mouse)
End	25,250,761 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; gastric mucosa; ; gallbladder; ; left uterine tube; ; anterior pituitary; ; tibial nerve; ; sural nerve; ; right lobe of liver; ; left lobe of thyroid gland; ; canal of the cervix;
	Top expressed in
	yolk sac; ; lip; ; superior frontal gyrus; ; lens; ; corneal stroma; ; female urethra; ; cumulus cell; ; entorhinal cortex; ; molar; ; left lobe of liver;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; transcription corepressor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; cytosol;
Biological process	cell differentiation; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; mitotic cell cycle; regulation of transcription by RNA polymerase II;
	Sources: Amigo / QuickGO
Orthologs
	2077
	13875
	ENSG00000105722
	ENSMUSG00000040857
	P50548
	P70459
	NM_001301035; NM_001308402; NM_001312656; NM_006494
	NM_010155
	NP_001287964; NP_001295331; NP_001299585; NP_006485
	NP_034285
	Wikidata
View/Edit Human	View/Edit Mouse

ETS domain-containing transcription factor ERF is a protein that in humans is encoded by the ERF gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105722 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040857 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sgouras DN, Athanasiou MA, Beal GJ, Fisher RJ, Blair DG, Mavrothalassitis GJ (October 1995). "ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation". The EMBO Journal. 14 (19): 4781–93. doi: 10.1002/j.1460-2075.1995.tb00160.x. PMC 394576. PMID 7588608.
^ de Castro CM, Rabe SM, Langdon SD, Fleenor DE, Slentz-Kesler K, Ahmed MN, Qumsiyeh MB, Kaufman RE (June 1997). "Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF)". Genomics. 42 (2): 227–35. doi: 10.1006/geno.1997.4730. PMID 9192842.
^ "Entrez Gene: ERF Ets2 repressor factor".

Liu D, Pavlopoulos E, Modi W, Moschonas N, Mavrothalassitis G (March 1997). "ERF: genomic organization, chromosomal localization and promoter analysis of the human and mouse genes". Oncogene. 14 (12): 1445–51. doi: 10.1038/sj.onc.1200965. PMID 9136988.
Le Gallic L, Sgouras D, Beal G, Mavrothalassitis G (June 1999). "Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation". Molecular and Cellular Biology. 19 (6): 4121–33. doi: 10.1128/mcb.19.6.4121. PMC 104371. PMID 10330152.
Dintilhac A, Bernués J (March 2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". The Journal of Biological Chemistry. 277 (9): 7021–8. doi: 10.1074/jbc.M108417200. hdl: 10261/112516. PMID 11748221.
Dubois T, Howell S, Zemlickova E, Aitken A (April 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. doi: 10.1016/S0014-5793(02)02614-5. PMID 12062430. S2CID 84792445.
Bain M, Mendelson M, Sinclair J (January 2003). "Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells". The Journal of General Virology. 84 (Pt 1): 41–9. doi: 10.1099/vir.0.18633-0. PMID 12533699.
Xiao X, Athanasiou M, Sidorov IA, Horikawa I, Cremona G, Blair D, Barret JC, Dimitrov DS (December 2003). "Role of Ets/Id proteins for telomerase regulation in human cancer cells". Experimental and Molecular Pathology. 75 (3): 238–47. doi: 10.1016/S0014-4800(03)00092-3. PMID 14611815.
Wolvetang EJ, Bradfield OM, Hatzistavrou T, Crack PJ, Busciglio J, Kola I, Hertzog PJ (December 2003). "Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis". Neurobiology of Disease. 14 (3): 349–56. doi: 10.1016/S0969-9961(03)00107-4. PMID 14678752. S2CID 30142532.
Le Gallic L, Virgilio L, Cohen P, Biteau B, Mavrothalassitis G (February 2004). "ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression". Molecular and Cellular Biology. 24 (3): 1206–18. doi: 10.1128/MCB.24.3.1206-1218.2004. PMC 321421. PMID 14729966.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi: 10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Hester KD, Verhelle D, Escoubet-Lozach L, Luna R, Rose DW, Glass CK (July 2007). "Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS". Cell Cycle. 6 (13): 1594–604. doi: 10.4161/cc.6.13.4336. PMID 17525531.
Verykokakis M, Papadaki C, Vorgia E, Le Gallic L, Mavrothalassitis G (October 2007). "The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression". The Journal of Biological Chemistry. 282 (41): 30285–94. doi: 10.1074/jbc.M704428200. PMID 17699159.

External links

ERF+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105722 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040857 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7588608-5] Sgouras DN, Athanasiou MA, Beal GJ, Fisher RJ, Blair DG, Mavrothalassitis GJ (October 1995). "ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation". The EMBO Journal. 14 (19): 4781–93. doi: 10.1002/j.1460-2075.1995.tb00160.x. PMC 394576. PMID 7588608.

[pmid9192842-6] Castro CM, Rabe SM, Langdon SD, Fleenor DE, Slentz-Kesler K, Ahmed MN, Qumsiyeh MB, Kaufman RE (June 1997). "Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF)". Genomics. 42 (2): 227–35. doi: 10.1006/geno.1997.4730. PMID 9192842.

[entrez-7] "Entrez Gene: ERF Ets2 repressor factor".

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