CBX3

CBX3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3TZD, 2L11, 3DM1, 3KUP
Identifiers
Aliases	CBX3, HECH, HP1-GAMMA, HP1Hs-gamma, chromobox 3
External IDs	OMIM: 604477 MGI: 108515 HomoloGene: 40583 GeneCards: CBX3
Gene location ( Human)
Chr.	Chromosome 7 (human)
End	26,213,607 bp
Gene location ( Mouse)
Chr.	Chromosome 6 (mouse)
End	51,460,684 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; ganglionic eminence; ; visceral pleura; ; parietal pleura; ; germinal epithelium; ; tibia; ; trabecular bone; ; endometrium; ; palpebral conjunctiva; ; Brodmann area 23;
	Top expressed in
	morula; ; yolk sac; ; superior frontal gyrus; ; lip; ; spermatid; ; spermatocyte; ; thymus; ; cerebellar cortex; ; neural tube; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; histone methyltransferase binding; protein binding; identical protein binding; enzyme binding;
Cellular component	nuclear envelope; spindle; nuclear inner membrane; chromatin; chromosome, centromeric region; nucleus; condensed chromosome, centromeric region; nucleoplasm; site of DNA damage; senescence-associated heterochromatin focus;
Biological process	chromatin remodeling; regulation of transcription, DNA-templated; rhythmic process; transcription, DNA-templated; negative regulation of transcription, DNA-templated; negative regulation of G0 to G1 transition; chromatin organization; cellular response to DNA damage stimulus; cellular response to dexamethasone stimulus;
	Sources: Amigo / QuickGO
Orthologs
	11335
	12417
	ENSG00000122565
	ENSMUSG00000029836
	Q13185
	P23198
	NM_007276; NM_016587
	NM_001037798; NM_007624; NM_001355002
	NP_009207; NP_057671
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans.^[5]^[6]

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.^[6]

Interactions

CBX3 has been shown to interact with PIM1,^[7] Ki-67,^[8] Lamin B receptor,^[9] CBX5^[10] and CBX1.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122565 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029836 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ye Q, Worman HJ (August 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J Biol Chem. 271 (25): 14653–6. doi: 10.1074/jbc.271.25.14653. PMID 8663349.
^ ^a ^b "Entrez Gene: CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila)".
^ Koike N, Maita H, Taira T, Ariga H, Iguchi-Ariga S M (February 2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)". FEBS Lett. 467 (1): 17–21. doi: 10.1016/S0014-5793(00)01105-4. ISSN 0014-5793. PMID 10664448. S2CID 29392124.
^ Kametaka A, Takagi Masatoshi, Hayakawa Tomohiro, Haraguchi Tokuko, Hiraoka Yasushi, Yoneda Yoshihiro (December 2002). "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins". Genes Cells. 7 (12): 1231–42. doi: 10.1046/j.1365-2443.2002.00596.x. ISSN 1356-9597. PMID 12485163. S2CID 6802841.
^ Ye Q, Worman H J (June 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J. Biol. Chem. 271 (25): 14653–6. doi: 10.1074/jbc.271.25.14653. ISSN 0021-9258. PMID 8663349.
^ ^a ^b Nielsen AL, Oulad-Abdelghani M, Ortiz J A, Remboutsika E, Chambon P, Losson R (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell. 7 (4): 729–39. doi: 10.1016/S1097-2765(01)00218-0. hdl: 10261/308369. ISSN 1097-2765. PMID 11336697.

Ye Q, Callebaut I, Pezhman A, et al. (1997). "Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR". J. Biol. Chem. 272 (23): 14983–9. doi: 10.1074/jbc.272.23.14983. PMID 9169472.
Lessard J, Baban S, Sauvageau G (1998). "Stage-specific expression of polycomb group genes in human bone marrow cells". Blood. 91 (4): 1216–24. doi: 10.1182/blood.V91.4.1216. PMID 9454751.
Seeler JS, Marchio A, Sitterlin D, et al. (1998). "Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7316–21. Bibcode: 1998PNAS...95.7316S. doi: 10.1073/pnas.95.13.7316. PMC 22602. PMID 9636146.
Lehming N, Le Saux A, Schüller J, Ptashne M (1998). "Chromatin components as part of a putative transcriptional repressing complex". Proc. Natl. Acad. Sci. U.S.A. 95 (13): 7322–6. Bibcode: 1998PNAS...95.7322L. doi: 10.1073/pnas.95.13.7322. PMC 22604. PMID 9636147.
Ainsztein AM, Kandels-Lewis SE, Mackay AM, Earnshaw WC (1999). "INCENP Centromere and Spindle Targeting: Identification of Essential Conserved Motifs and Involvement of Heterochromatin Protein HP1". J. Cell Biol. 143 (7): 1763–74. doi: 10.1083/jcb.143.7.1763. PMC 2175214. PMID 9864353.
Ryan RF, Schultz DC, Ayyanathan K, et al. (1999). "KAP-1 Corepressor Protein Interacts and Colocalizes with Heterochromatic and Euchromatic HP1 Proteins: a Potential Role for Krüppel-Associated Box–Zinc Finger Proteins in Heterochromatin-Mediated Gene Silencing". Mol. Cell. Biol. 19 (6): 4366–78. doi: 10.1128/mcb.19.6.4366. PMC 104396. PMID 10330177.
Minc E, Allory Y, Worman HJ, et al. (1999). "Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells". Chromosoma. 108 (4): 220–34. doi: 10.1007/s004120050372. PMID 10460410. S2CID 12381860.
Nielsen AL, Ortiz JA, You J, et al. (2000). "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family". EMBO J. 18 (22): 6385–95. doi: 10.1093/emboj/18.22.6385. PMC 1171701. PMID 10562550.
Koike N, Maita H, Taira T, et al. (2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)". FEBS Lett. 467 (1): 17–21. doi: 10.1016/S0014-5793(00)01105-4. PMID 10664448. S2CID 29392124.
Minc E, Courvalin JC, Buendia B (2001). "HP1gamma associates with euchromatin and heterochromatin in mammalian nuclei and chromosomes". Cytogenet. Cell Genet. 90 (3–4): 279–84. doi: 10.1159/000056789. PMID 11124534. S2CID 24349769.
Lachner M, O'Carroll D, Rea S, et al. (2001). "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins". Nature. 410 (6824): 116–20. Bibcode: 2001Natur.410..116L. doi: 10.1038/35065132. PMID 11242053. S2CID 4331863.
Nielsen AL, Oulad-Abdelghani M, Ortiz JA, et al. (2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell. 7 (4): 729–39. doi: 10.1016/S1097-2765(01)00218-0. hdl: 10261/308369. PMID 11336697.
Scholzen T, Endl E, Wohlenberg C, et al. (2002). "The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure". J. Pathol. 196 (2): 135–44. doi: 10.1002/path.1016. PMID 11793364. S2CID 36130549.
Vassallo MF, Tanese N (2002). "Isoform-specific interaction of HP1 with human TAFII130". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 5919–24. Bibcode: 2002PNAS...99.5919V. doi: 10.1073/pnas.092025499. PMC 122877. PMID 11959914.
Ogawa H, Ishiguro K, Gaubatz S, et al. (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6. Bibcode: 2002Sci...296.1132O. doi: 10.1126/science.1069861. PMID 12004135. S2CID 34863978.
Hwang KK, Worman HJ (2002). "Gene regulation by human orthologs of Drosophila heterochromatin protein 1". Biochem. Biophys. Res. Commun. 293 (4): 1217–22. doi: 10.1016/S0006-291X(02)00377-7. PMID 12054505.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kametaka A, Takagi M, Hayakawa T, et al. (2003). "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins". Genes Cells. 7 (12): 1231–42. doi: 10.1046/j.1365-2443.2002.00596.x. PMID 12485163. S2CID 6802841.
Cheutin T, McNairn AJ, Jenuwein T, et al. (2003). "Maintenance of stable heterochromatin domains by dynamic HP1 binding". Science. 299 (5607): 721–5. Bibcode: 2003Sci...299..721C. doi: 10.1126/science.1078572. PMID 12560555. S2CID 32776616.

External links

CBX3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CBX3 genome location and CBX3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122565 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029836 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8663349-5] Ye Q, Worman HJ (August 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J Biol Chem. 271 (25): 14653–6. doi: 10.1074/jbc.271.25.14653. PMID 8663349.

[entrez-6] "Entrez Gene: CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila)".

[pmid10664448-7] Koike N, Maita H, Taira T, Ariga H, Iguchi-Ariga S M (February 2000). "Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)". FEBS Lett. 467 (1): 17–21. doi: 10.1016/S0014-5793(00)01105-4. ISSN 0014-5793. PMID 10664448. S2CID 29392124.

[pmid12485163-8] Kametaka A, Takagi Masatoshi, Hayakawa Tomohiro, Haraguchi Tokuko, Hiraoka Yasushi, Yoneda Yoshihiro (December 2002). "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins". Genes Cells. 7 (12): 1231–42. doi: 10.1046/j.1365-2443.2002.00596.x. ISSN 1356-9597. PMID 12485163. S2CID 6802841.

[autogenerated1-9] Ye Q, Worman H J (June 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J. Biol. Chem. 271 (25): 14653–6. doi: 10.1074/jbc.271.25.14653. ISSN 0021-9258. PMID 8663349.

[pmid11336697-10] Nielsen AL, Oulad-Abdelghani M, Ortiz J A, Remboutsika E, Chambon P, Losson R (April 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell. 7 (4): 729–39. doi: 10.1016/S1097-2765(01)00218-0. hdl: 10261/308369. ISSN 1097-2765. PMID 11336697.

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Interactions

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References

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