The gene PKD2 also known as TRPP2, encodes a member of the polycystin protein family, called
TRPP, and contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP2 may function in
renal tubular development, morphology, and function, and may modulate intracellular
calcium homeostasis and other
signal transduction pathways. This protein interacts with
polycystin 1 (TRPP1) to produce
cation-permeable currents. It was discovered by
Stefan Somlo at
Yale University.
Illustration of PKD1 and PKD2 proteins at the cell membrane
^Li Q, Shen PY, Wu G, Chen XZ (January 2003). "Polycystin-2 interacts with troponin I, an angiogenesis inhibitor". Biochemistry. 42 (2): 450–457.
doi:
10.1021/bi0267792.
PMID12525172.
Further reading
Islam MS (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. Vol. 704. Berlin: Springer. p. 700.
ISBN978-94-007-0264-6.
Hayashi T, Mochizuki T, Reynolds DM, Wu G, Cai Y, Somlo S (August 1997). "Characterization of the exon structure of the polycystic kidney disease 2 gene (PKD2)". Genomics. 44 (1): 131–136.
doi:
10.1006/geno.1997.4851.
PMID9286709.
The gene PKD2 also known as TRPP2, encodes a member of the polycystin protein family, called
TRPP, and contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP2 may function in
renal tubular development, morphology, and function, and may modulate intracellular
calcium homeostasis and other
signal transduction pathways. This protein interacts with
polycystin 1 (TRPP1) to produce
cation-permeable currents. It was discovered by
Stefan Somlo at
Yale University.
Illustration of PKD1 and PKD2 proteins at the cell membrane
^Li Q, Shen PY, Wu G, Chen XZ (January 2003). "Polycystin-2 interacts with troponin I, an angiogenesis inhibitor". Biochemistry. 42 (2): 450–457.
doi:
10.1021/bi0267792.
PMID12525172.
Further reading
Islam MS (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. Vol. 704. Berlin: Springer. p. 700.
ISBN978-94-007-0264-6.
Hayashi T, Mochizuki T, Reynolds DM, Wu G, Cai Y, Somlo S (August 1997). "Characterization of the exon structure of the polycystic kidney disease 2 gene (PKD2)". Genomics. 44 (1): 131–136.
doi:
10.1006/geno.1997.4851.
PMID9286709.