The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a
protein that in humans is encoded by the TRPC4gene.[5][6]
Deletion of the trpc4 gene decreases levels of sociability in a social exploration task. These results suggest that TRPC4 may play a role in regulating social anxiety in a number of different disorders.[10] However deletion of the trpc4 gene had no impact on basic or complex strategic learning.[11] Given that the trpc4 gene is expressed in a select population of midbrain dopamine neurons, it has been proposed that it may have an important role in dopamine related processes including addiction and attention.[9]
^Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50.
doi:
10.1124/pr.57.4.6.
PMID16382100.
S2CID17936350.
^
abCooper D, Illig K, Varnell A, Ostertag E, Klipec W (2011). "TRPC4 ion channel protein is selectively expressed in a subpopulation of dopamine neurons in the ventral tegmental area". Nature Precedings.
arXiv:1204.0142.
doi:
10.1038/npre.2011.6577.1.
S2CID19188350.
Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. Vol. 704. Berlin: Springer. p. 700.
ISBN978-94-007-0264-6.
Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50.
doi:
10.1124/pr.57.4.6.
PMID16382100.
S2CID17936350.
The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a
protein that in humans is encoded by the TRPC4gene.[5][6]
Deletion of the trpc4 gene decreases levels of sociability in a social exploration task. These results suggest that TRPC4 may play a role in regulating social anxiety in a number of different disorders.[10] However deletion of the trpc4 gene had no impact on basic or complex strategic learning.[11] Given that the trpc4 gene is expressed in a select population of midbrain dopamine neurons, it has been proposed that it may have an important role in dopamine related processes including addiction and attention.[9]
^Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50.
doi:
10.1124/pr.57.4.6.
PMID16382100.
S2CID17936350.
^
abCooper D, Illig K, Varnell A, Ostertag E, Klipec W (2011). "TRPC4 ion channel protein is selectively expressed in a subpopulation of dopamine neurons in the ventral tegmental area". Nature Precedings.
arXiv:1204.0142.
doi:
10.1038/npre.2011.6577.1.
S2CID19188350.
Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. Vol. 704. Berlin: Springer. p. 700.
ISBN978-94-007-0264-6.
Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50.
doi:
10.1124/pr.57.4.6.
PMID16382100.
S2CID17936350.