AQP5

AQP5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3D9S, 5C5X, 5DYE
Identifiers
Aliases	AQP5, AQP-5, PPKB, aquaporin 5
External IDs	OMIM: 600442; MGI: 106215; HomoloGene: 20398; GeneCards: AQP5; OMA: AQP5 - orthologs
Gene location ( Human)
Chr.	Chromosome 12 (human)
End	49,965,682 bp
Gene location ( Mouse)
Chr.	Chromosome 15 (mouse)
End	99,492,710 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; palpebral conjunctiva; ; left testis; ; right testis; ; parotid gland; ; skin of leg; ; nasal epithelium; ; minor salivary glands; ; trachea; ; skin of abdomen;
	Top expressed in
	submandibular gland; ; parotid gland; ; lacrimal gland; ; right lung; ; right lung lobe; ; respiratory epithelium; ; olfactory epithelium; ; trachea; ; epithelium of lens; ; left lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; protein binding; water channel activity; identical protein binding; channel activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; microvillus; basal plasma membrane; apical plasma membrane; endoplasmic reticulum; extracellular exosome; cytoplasmic vesicle membrane; cytoplasmic vesicle;
Biological process	excretion; water transport; pancreatic juice secretion; saliva secretion; odontogenesis; ion transmembrane transport; camera-type eye morphogenesis; carbon dioxide transport; transport; transmembrane transport; protein homotetramerization; cellular hypotonic response;
	Sources: Amigo / QuickGO
Orthologs
	362
	11830
	ENSG00000161798
	ENSMUSG00000044217
	P55064
	Q9WTY4
	NM_001651
	NM_009701
	NP_001642
	NP_033831
	Wikidata
View/Edit Human	View/Edit Mouse

Aquaporin-5 (AQP-5) is a protein that in humans is encoded by the AQP5 gene.^[5]^[6]

Aquaporin-5 (AQP-5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-5 plays a role in the generation of saliva, tears and pulmonary secretions.^[6] AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161798 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044217 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee MD, Bhakta KY, Raina S, Yonescu R, Griffin CA, Copeland NG, Gilbert DJ, Jenkins NA, Preston GM, Agre P (Jun 1996). "The human Aquaporin-5 gene. Molecular characterization and chromosomal localization". J Biol Chem. 271 (15): 8599–604. doi: 10.1074/jbc.271.15.8599. PMID 8621489.
^ ^a ^b ^c "Entrez Gene: AQP5 aquaporin 5".

Verkman AS (2003). "Role of aquaporin water channels in eye function". Exp. Eye Res. 76 (2): 137–43. doi: 10.1016/S0014-4835(02)00303-2. PMID 12565800.
Ma T, Yang B, Umenishi F, Verkman AS (1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13". Genomics. 43 (3): 387–9. doi: 10.1006/geno.1997.4836. PMID 9268644.
Smith JK, Siddiqui AA, Modica LA, et al. (1999). "Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands". J. Interferon Cytokine Res. 19 (8): 929–35. doi: 10.1089/107999099313479. PMID 10476940.
Kreda SM, Gynn MC, Fenstermacher DA, et al. (2001). "Expression and localization of epithelial aquaporins in the adult human lung". Am. J. Respir. Cell Mol. Biol. 24 (3): 224–34. doi: 10.1165/ajrcmb.24.3.4367. PMID 11245621. S2CID 12825671.
Gresz V, Kwon TH, Hurley PT, et al. (2001). "Identification and localization of aquaporin water channels in human salivary glands". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G247–54. doi: 10.1152/ajpgi.2001.281.1.G247. PMID 11408278.
Nejsum LN, Kwon TH, Jensen UB, et al. (2002). "Functional requirement of aquaporin-5 in plasma membranes of sweat glands". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 511–6. Bibcode: 2002PNAS...99..511N. doi: 10.1073/pnas.012588099. PMC 117591. PMID 11773623.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Burghardt B, Elkaer ML, Kwon TH, et al. (2003). "Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas". Gut. 52 (7): 1008–16. doi: 10.1136/gut.52.7.1008. PMC 1773699. PMID 12801959.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode: 2005Natur.437.1173R. doi: 10.1038/nature04209. PMID 16189514. S2CID 4427026.
Chen Z, Wang X, Gao L, et al. (2006). "Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells". Biochem. Biophys. Res. Commun. 342 (3): 775–81. doi: 10.1016/j.bbrc.2006.01.103. PMID 16500622.
Sidhaye VK, Güler AD, Schweitzer KS, et al. (2006). "Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions". Proc. Natl. Acad. Sci. U.S.A. 103 (12): 4747–52. Bibcode: 2006PNAS..103.4747S. doi: 10.1073/pnas.0511211103. PMC 1450241. PMID 16537379.
Pedersen PS, Braunstein TH, Jørgensen A, et al. (2007). "Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress". Pflügers Arch. 453 (6): 777–85. doi: 10.1007/s00424-006-0157-3. PMID 17043812. S2CID 6205954.
Skowron-zwarg M, Boland S, Caruso N, et al. (2007). "Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation". Exp. Cell Res. 313 (12): 2695–702. doi: 10.1016/j.yexcr.2007.02.035. PMID 17553491.

External links

AQP5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human AQP5 genome location and AQP5 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000161798 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044217 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8621489-5] Lee MD, Bhakta KY, Raina S, Yonescu R, Griffin CA, Copeland NG, Gilbert DJ, Jenkins NA, Preston GM, Agre P (Jun 1996). "The human Aquaporin-5 gene. Molecular characterization and chromosomal localization". J Biol Chem. 271 (15): 8599–604. doi: 10.1074/jbc.271.15.8599. PMID 8621489.

[entrez-6] "Entrez Gene: AQP5 aquaporin 5".

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