Kv channel-interacting protein 1 also known as KChIP1 is a
protein that in humans is encoded by the KCNIP1gene.[5][6]
Function
This gene encodes a member of the family of voltage-gated potassium (
Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the
recoverin branch of the
EF-hand superfamily.[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the
N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[6]
Pruunsild P, Timmusk T (2005). "Structure, alternative splicing, and expression of the human and mouse KCNIP gene family". Genomics. 86 (5): 581–593.
doi:
10.1016/j.ygeno.2005.07.001.
PMID16112838.
Kv channel-interacting protein 1 also known as KChIP1 is a
protein that in humans is encoded by the KCNIP1gene.[5][6]
Function
This gene encodes a member of the family of voltage-gated potassium (
Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the
recoverin branch of the
EF-hand superfamily.[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the
N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[6]
Pruunsild P, Timmusk T (2005). "Structure, alternative splicing, and expression of the human and mouse KCNIP gene family". Genomics. 86 (5): 581–593.
doi:
10.1016/j.ygeno.2005.07.001.
PMID16112838.