Two pore segment channel 1 (TPC1) is a human
protein encoded by the TPCN1gene.[5] The protein encoded by this gene is an
ion channel. In contrast to other
calcium and
sodium channels which have four homologous domains, each containing six transmembrane segments (S1 to S6), TPCN1 only contains two domains (each containing segments S1 to S6).[6][7][8]
Genetic knockout and pharmacological inhibition experiments demonstrate that the
two-pore channels,
TPC1 and
TPC2, are required for infection by Filoviruses
Ebola and
Marburg in mice.[11]
^Ishibashi K, Suzuki M, Imai M (April 2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels". Biochemical and Biophysical Research Communications. 270 (2): 370–6.
doi:
10.1006/bbrc.2000.2435.
PMID10753632.
^Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacological Reviews. 57 (4): 451–4.
doi:
10.1124/pr.57.4.7.
PMID16382101.
S2CID35096827.
Ishibashi K, Suzuki M, Imai M (April 2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels". Biochemical and Biophysical Research Communications. 270 (2): 370–6.
doi:
10.1006/bbrc.2000.2435.
PMID10753632.
Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacological Reviews. 57 (4): 451–4.
doi:
10.1124/pr.57.4.7.
PMID16382101.
S2CID35096827.
Two pore segment channel 1 (TPC1) is a human
protein encoded by the TPCN1gene.[5] The protein encoded by this gene is an
ion channel. In contrast to other
calcium and
sodium channels which have four homologous domains, each containing six transmembrane segments (S1 to S6), TPCN1 only contains two domains (each containing segments S1 to S6).[6][7][8]
Genetic knockout and pharmacological inhibition experiments demonstrate that the
two-pore channels,
TPC1 and
TPC2, are required for infection by Filoviruses
Ebola and
Marburg in mice.[11]
^Ishibashi K, Suzuki M, Imai M (April 2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels". Biochemical and Biophysical Research Communications. 270 (2): 370–6.
doi:
10.1006/bbrc.2000.2435.
PMID10753632.
^Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacological Reviews. 57 (4): 451–4.
doi:
10.1124/pr.57.4.7.
PMID16382101.
S2CID35096827.
Ishibashi K, Suzuki M, Imai M (April 2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels". Biochemical and Biophysical Research Communications. 270 (2): 370–6.
doi:
10.1006/bbrc.2000.2435.
PMID10753632.
Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacological Reviews. 57 (4): 451–4.
doi:
10.1124/pr.57.4.7.
PMID16382101.
S2CID35096827.