Transient receptor potential cation channel subfamily M member 3 is a
protein that in humans is encoded by the TRPM3gene.[5]
Function
The product of this gene belongs to the family of
transient receptor potential (TRP) channels.[6] TRP channels are Ca2+ permeable non-selective
cation channels that play roles in a wide variety of physiological processes, including
calcium signaling,
heat and cold sensation, calcium and magnesium homeostasis. TRPMs mediates sodium and calcium entry, which induces
depolarization and a cytoplasmic
Ca2+ signal. Alternatively spliced transcript variants encoding different isoforms have been -identified.[7]
TRPM3 was shown to be activated by the
neurosteroidpregnenolone sulfate as well as the synthetic compound
CIM0216.
Peripheral heat sensation
TRPM3 is expressed in peripheral sensory neurons of the
dorsal root ganglia, and they are activated by high temperatures.[8] Genetic deletion of TRPM3 in mice reduces sensitivity to noxious heat, as well as inflammatory thermal
hyperalgesia.[8][9] Inhibitors of TRPM3 were also shown to reduce noxious heat and inflammatory heat hyperalgesia,[10][11][9] as well as reduce heat hyperalgesia and spontaneous pain in nerve injury induced neuropathic pain.[9]
Mutations in TRPM3 in humans, were recently shown to cause a intellectual disability and
epilepsy.[17] The disease associated mutations were shown to increase the sensitivity of the channel to agonists, and heat.[18][19][20]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50.
doi:
10.1124/pr.57.4.6.
PMID16382100.
S2CID17936350.
Transient receptor potential cation channel subfamily M member 3 is a
protein that in humans is encoded by the TRPM3gene.[5]
Function
The product of this gene belongs to the family of
transient receptor potential (TRP) channels.[6] TRP channels are Ca2+ permeable non-selective
cation channels that play roles in a wide variety of physiological processes, including
calcium signaling,
heat and cold sensation, calcium and magnesium homeostasis. TRPMs mediates sodium and calcium entry, which induces
depolarization and a cytoplasmic
Ca2+ signal. Alternatively spliced transcript variants encoding different isoforms have been -identified.[7]
TRPM3 was shown to be activated by the
neurosteroidpregnenolone sulfate as well as the synthetic compound
CIM0216.
Peripheral heat sensation
TRPM3 is expressed in peripheral sensory neurons of the
dorsal root ganglia, and they are activated by high temperatures.[8] Genetic deletion of TRPM3 in mice reduces sensitivity to noxious heat, as well as inflammatory thermal
hyperalgesia.[8][9] Inhibitors of TRPM3 were also shown to reduce noxious heat and inflammatory heat hyperalgesia,[10][11][9] as well as reduce heat hyperalgesia and spontaneous pain in nerve injury induced neuropathic pain.[9]
Mutations in TRPM3 in humans, were recently shown to cause a intellectual disability and
epilepsy.[17] The disease associated mutations were shown to increase the sensitivity of the channel to agonists, and heat.[18][19][20]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacological Reviews. 57 (4): 427–50.
doi:
10.1124/pr.57.4.6.
PMID16382100.
S2CID17936350.