RQ-00203078 is a drug which acts as a potent and selective blocker of the
TRPM8ion channel, which is the main receptor responsible for the sensation of
cold. It was developed as a potential
analgesic, and blocks the development of
hyperalgesia following exposure to cold temperatures or chronic
morphine administration.[1][2][3]
^Ohmi M, Shishido Y, Inoue T, Ando K, Fujiuchi A, Yamada A, et al. (December 2014). "Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist". Bioorganic & Medicinal Chemistry Letters. 24 (23): 5364–8.
doi:
10.1016/j.bmcl.2014.10.074.
PMID25455182.
RQ-00203078 is a drug which acts as a potent and selective blocker of the
TRPM8ion channel, which is the main receptor responsible for the sensation of
cold. It was developed as a potential
analgesic, and blocks the development of
hyperalgesia following exposure to cold temperatures or chronic
morphine administration.[1][2][3]
^Ohmi M, Shishido Y, Inoue T, Ando K, Fujiuchi A, Yamada A, et al. (December 2014). "Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist". Bioorganic & Medicinal Chemistry Letters. 24 (23): 5364–8.
doi:
10.1016/j.bmcl.2014.10.074.
PMID25455182.