From Wikipedia, the free encyclopedia
Chemical compound
HC-030031 is a drug which acts as a potent and selective
antagonist for the
TRPA1 receptor, and has
analgesic and
antiinflammatory effects.
[1]
[2]
[3]
[4]
References
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^ Eid SR, Crown ED, Moore EL, Liang HA, Choong KC, Dima S, et al. (October 2008).
"HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity". Molecular Pain. 4: 1744-8069–4-48.
doi:
10.1186/1744-8069-4-48.
PMC
2584039.
PMID
18954467.
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^ Pereira LM, Lima-Júnior RC, Bem AX, Teixeira CG, Grassi LS, Medeiros RP, et al. (February 2013).
"Blockade of TRPA1 with HC-030031 attenuates visceral nociception by a mechanism independent of inflammatory resident cells, nitric oxide and the opioid system". European Journal of Pain. 17 (2): 223–33.
doi:
10.1002/j.1532-2149.2012.00177.x.
PMID
22689151.
S2CID
9421113.
-
^ Koivisto A, Chapman H, Jalava N, Korjamo T, Saarnilehto M, Lindstedt K, Pertovaara A (January 2014).
"TRPA1: a transducer and amplifier of pain and inflammation". Basic & Clinical Pharmacology & Toxicology. 114 (1): 50–5.
doi:
10.1111/bcpt.12138.
PMID
24102997.
-
^ Achanta S, Chintagari NR, Brackmann M, Balakrishna S, Jordt SE (September 2018).
"TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation". Toxicology Letters. 293: 140–148.
doi:
10.1016/j.toxlet.2018.03.007.
PMC
5975083.
PMID
29535050.
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TRPA | Activators |
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4-Hydroxynonenal
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4-Oxo-2-nonenal
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4,5-EET
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12S-HpETE
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15-Deoxy-Δ12,14-prostaglandin J2
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α-Sanshool (
ginger,
Sichuan and
melegueta peppers)
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Acrolein
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Allicin (
garlic)
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Allyl isothiocyanate (
mustard,
radish,
horseradish,
wasabi)
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AM404
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ASP-7663
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Bradykinin
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Cannabichromene (
cannabis)
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Cannabidiol (
cannabis)
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Cannabigerol (
cannabis)
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Cinnamaldehyde (
cinnamon)
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CR gas (dibenzoxazepine; DBO)
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CS gas (2-chlorobenzal malononitrile)
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Cuminaldehyde (
cumin)
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Curcumin (
turmeric)
-
Dehydroligustilide (
celery)
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Diallyl disulfide
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Dicentrine (
Lindera spp.)
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Farnesyl thiosalicylic acid
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Formalin
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Gingerols (
ginger)
-
Hepoxilin A3
-
Hepoxilin B3
-
Hydrogen peroxide
-
Icilin
-
Isothiocyanate
-
JT-010
-
Ligustilide (
celery,
Angelica acutiloba)
-
Linalool (
Sichuan pepper,
thyme)
-
Methylglyoxal
-
Methyl salicylate (
wintergreen)
-
N-Methylmaleimide
-
Nicotine (
tobacco)
-
Oleocanthal (
olive oil)
-
Paclitaxel (
Pacific yew)
-
Paracetamol (acetaminophen)
-
PF-4840154
-
Phenacyl chloride
-
Polygodial (
Dorrigo pepper)
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Shogaols (
ginger,
Sichuan and
melegueta peppers)
-
Tear gases
-
Tetrahydrocannabinol (
cannabis)
-
Tetrahydrocannabiorcol
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Thiopropanal S-oxide (
onion)
-
Umbellulone (Umbellularia californica)
-
WIN 55,212-2
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Blockers | |
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TRPC | |
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TRPM | |
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TRPML | |
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TRPP | |
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TRPV | Activators |
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2-APB
-
5',6'-EET
-
9-HODE
-
9-oxoODE
-
12S-HETE
-
12S-HpETE
-
13-HODE
-
13-oxoODE
-
20-HETE
-
α-Sanshool (
ginger,
Sichuan and
melegueta peppers)
-
Allicin (
garlic)
-
AM404
-
Anandamide
-
Bisandrographolide (
Andrographis paniculata)
-
Camphor (
camphor laurel,
rosemary,
camphorweed,
African blue basil,
camphor basil)
-
Cannabidiol (
cannabis)
-
Cannabidivarin (
cannabis)
-
Capsaicin (
chili pepper)
-
Carvacrol (
oregano,
thyme,
pepperwort,
wild bergamot, others)
-
DHEA
-
Diacyl glycerol
-
Dihydrocapsaicin (
chili pepper)
-
Estradiol
-
Eugenol (
basil,
clove)
-
Evodiamine (
Euodia ruticarpa)
-
Gingerols (
ginger)
-
GSK1016790A
-
Heat
-
Hepoxilin A3
-
Hepoxilin B3
-
Homocapsaicin (
chili pepper)
-
Homodihydrocapsaicin (
chili pepper)
-
Incensole (
incense)
-
Lysophosphatidic acid
- Low
pH (acidic conditions)
-
Menthol (
mint)
-
N-Arachidonoyl dopamine
-
N-Oleoyldopamine
-
N-Oleoylethanolamide
-
Nonivamide (PAVA) (
PAVA spray)
-
Nordihydrocapsaicin (
chili pepper)
-
Paclitaxel (
Pacific yew)
-
Paracetamol (acetaminophen)
-
Phenylacetylrinvanil
-
Phorbol esters (e.g.,
4α-PDD)
-
Piperine (
black pepper,
long pepper)
-
Polygodial (
Dorrigo pepper)
-
Probenecid
-
Protons
-
RhTx
-
Rutamarin (
Ruta graveolens)
-
Resiniferatoxin (RTX) (
Euphorbia resinifera/
pooissonii)
-
Shogaols (
ginger,
Sichuan and
melegueta peppers)
-
Tetrahydrocannabivarin (
cannabis)
-
Thymol (
thyme,
oregano)
-
Tinyatoxin (
Euphorbia resinifera/
pooissonii)
-
Tramadol
-
Vanillin (
vanilla)
-
Zucapsaicin
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Blockers | |
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