Clinical data | |
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Other names | JNJ-39439335 |
Identifiers | |
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CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C25H21F3N2O |
Molar mass | 422.451 g·mol−1 |
3D model ( JSmol) | |
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Mavatrep (JNJ‐39439335) is a TRPV1 receptor selective competitive antagonist. [1] It is an investigational analgesic that may be a potential treatment for pain and/or inflammation.
Phase I trials have been completed in healthy Japanese and Caucasian volunteers. [1] [2]
Potential common adverse effects include thermohypoesthesia, chills, feeling cold, and feeling hot. [2]
When administered orally once a day, mavatrep reached steady-state in healthy volunteers in approximately 14 days. [2] It has a relatively long half life between 68 and 101 hours in Japanese subjects and between 82 and 130 hours in Caucasian subjects. [2]
Mavatrep is largely eliminated nonrenally. Mavatrep appears to be metabolized into two primary metabolites which are also eliminated nonrenally. [2]
Clinical data | |
---|---|
Other names | JNJ-39439335 |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
Chemical and physical data | |
Formula | C25H21F3N2O |
Molar mass | 422.451 g·mol−1 |
3D model ( JSmol) | |
| |
|
Mavatrep (JNJ‐39439335) is a TRPV1 receptor selective competitive antagonist. [1] It is an investigational analgesic that may be a potential treatment for pain and/or inflammation.
Phase I trials have been completed in healthy Japanese and Caucasian volunteers. [1] [2]
Potential common adverse effects include thermohypoesthesia, chills, feeling cold, and feeling hot. [2]
When administered orally once a day, mavatrep reached steady-state in healthy volunteers in approximately 14 days. [2] It has a relatively long half life between 68 and 101 hours in Japanese subjects and between 82 and 130 hours in Caucasian subjects. [2]
Mavatrep is largely eliminated nonrenally. Mavatrep appears to be metabolized into two primary metabolites which are also eliminated nonrenally. [2]